Resistant starch and arabinoxylan augment SCFA absorption, but affect postprandial glucose and insulin responses differently

TY - JOUR

T1 - Resistant starch and arabinoxylan augment SCFA absorption, but affect postprandial glucose and insulin responses differently

AU - Ingerslev, Anne Krog

AU - Theil, Peter Kappel

AU - Hedemann, Mette Skou

AU - Lærke, Helle Nygaard

AU - Knudsen, Knud Erik Bach

PY - 2014/5

Y1 - 2014/5

N2 - The effects of increased colonic fermentation of dietary fibres (DF) on net portal flux (NPF) of carbohydrate-derived metabolites (glucose, SCFA and especially butyrate), hormones (insulin, C-peptide, GLP-1, GIP) and NEFA were studied in a healthy catheterised pig model. Six 59 ± 3.8 kg pigs were fitted with catheters in the mesenteric artery, the portal and hepatic vein, and a flowprobe around the portal vein and included in a double 3x3 crossover design with three daily feedings (at 9.00, 14.00 and 19.00 hours). Fasting and 5 hours postprandial blood samples were collected after 7 days adaptation to each diet. The pigs were fed a low DF western style control diet (WSD) and two high DF diets; an arabinoxylan (AXD) and a resistant starch (RSD) enriched diet. The NPF of insulin was lower (P = 0.04) in AXD fed pigs (4.6 nmol/h) compared to RSD fed pigs (10.5 nmol/h), despite the lowest NPF of glucose was observed in RSD fed pigs (203 mmol/h, P = 0.02). The NPF of total SCFA, acetate, propionate, and butyrate were high, intermediate, and low (P < 0.01) in AXD, RSD, and WSD fed pigs, respectively, with the largest relative increase for butyrate in response to arabinoxylan supplementation. In conclusion, RSD and AXD had different effects on net portal insulin and glucose flux, suggesting different impact of arabinoxylan and resistant starch on human health.

AB - The effects of increased colonic fermentation of dietary fibres (DF) on net portal flux (NPF) of carbohydrate-derived metabolites (glucose, SCFA and especially butyrate), hormones (insulin, C-peptide, GLP-1, GIP) and NEFA were studied in a healthy catheterised pig model. Six 59 ± 3.8 kg pigs were fitted with catheters in the mesenteric artery, the portal and hepatic vein, and a flowprobe around the portal vein and included in a double 3x3 crossover design with three daily feedings (at 9.00, 14.00 and 19.00 hours). Fasting and 5 hours postprandial blood samples were collected after 7 days adaptation to each diet. The pigs were fed a low DF western style control diet (WSD) and two high DF diets; an arabinoxylan (AXD) and a resistant starch (RSD) enriched diet. The NPF of insulin was lower (P = 0.04) in AXD fed pigs (4.6 nmol/h) compared to RSD fed pigs (10.5 nmol/h), despite the lowest NPF of glucose was observed in RSD fed pigs (203 mmol/h, P = 0.02). The NPF of total SCFA, acetate, propionate, and butyrate were high, intermediate, and low (P < 0.01) in AXD, RSD, and WSD fed pigs, respectively, with the largest relative increase for butyrate in response to arabinoxylan supplementation. In conclusion, RSD and AXD had different effects on net portal insulin and glucose flux, suggesting different impact of arabinoxylan and resistant starch on human health.

KW - Dietary fibres

KW - Insulin

KW - SCFA

KW - Porto-arterial catherised pigs

U2 - 10.1017/S0007114513004066

DO - 10.1017/S0007114513004066

M3 - Journal article

C2 - 24507768

SN - 0007-1145

VL - 111

SP - 1564

EP - 1576

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 9

ER -