Reproductive factors, exogenous hormone use and risk of B-cell non-Hodgkin lymphoma in a cohort of women from the European Prospective Investigation into Cancer and Nutrition

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  • Laura Costas, Unit of Molecular Epidemiology and Genetics in Infections and Cancer. Cancer Epidemiology Research Programme. Bellvitge Biomedical Research Institute (IDIBELL). Catalan Institute of Oncology., Spanien
  • Leila Lujan-Barroso, Department of Nursing of Public Health, Mental Health and Maternity and Child Health School of Nursing Universitat de Barcelona,Spain., Spanien
  • Yolanda Benavente, CIBERESP, Consortium for Biomedical Research in Epidemiology and Public Health, Spanien
  • Naomi E Allen, Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK., Storbritannien
  • Pilar Amiano, Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, Madrid, Spain; BIODONOSTIA Health Research Institute, Dr. Begiristain Pasealekua, San Sebastian 20014, Spain; University of the Basque Country (UPV/EHU), Preventative Medicine and Public Health Department, Faculty of Medicine, Leioa 48940, Spain; Public Health Division of Gipuzkoa, Basque Government, 4 Av. de Navarra, San Sebastian 20013, Spain., Spanien
  • Eva Ardanaz, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Spanien
  • Caroline Besson, 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Paris-Sud University, UMRS 1018, F-94805 Villejuif, France [3] Institut Gustave Roussy, F-94805 Villejuif, France., Frankrig
  • Heiner Boeing, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114 - 116, 14558 Nuthetal, Germany., Tyskland
  • Bas Bueno-de-Mesquita, Academic Icon / visiting professor, Dept. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, 50603, Kuala Lumpur, Malaysia., Malaysia
  • Iris Cervenka, 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Paris-Sud University, UMRS 1018, F-94805 Villejuif, France [3] Institut Gustave Roussy, F-94805 Villejuif, France., Frankrig
  • R Enée T Fortner, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Agnès Fournier, 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Paris-Sud University, UMRS 1018, F-94805 Villejuif, France [3] Institut Gustave Roussy, F-94805 Villejuif, France., Frankrig
  • Marc Gunter, International Agency for Research on Cancer.World Health Organization. Lyon, France., Frankrig
  • Sophia Harlid, Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden., Sverige
  • José María Huerta, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Spanien
  • Mats Jerkeman, Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, SE22185 Lund, Sweden., Sverige
  • Karin Jirström, Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, SE22185 Lund, Sweden., Sverige
  • Rudolf Kaaks, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Anna Karakatsani, 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Grækenland
  • Kay-Tee Khaw, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Storbritannien
  • Anastasia Kotanidou, 1st Department of Critical Care Medicine & Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, 10675 Athens, Greece. akotanid@gmail.com., Grækenland
  • Eiliv Lund, Department of Community Medicine, UiT The Arctic University of Norway, Pb 6070 Langnes, NO-9037 Tromsø, Norway., Norge
  • Giovanna Masala, Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy., Italien
  • Amalia Mattiello, Dipartimento di Medicina Clinica e Chirugia Federico II University, Naples Italy., Italien
  • Beatrice Melin, Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden., Sverige
  • Virginia Menéndez, Public Health Directorate, Asturias, Spain., Spanien
  • Neil Murphy, International Agency for Research on Cancer.World Health Organization. Lyon, France., Frankrig
  • Alexandra Nieters, Medical Center - University of Freiburg, Center for Chronic Immunodeficiency, at Center for Translational Cell Research., Tyskland
  • Kim Overvad
  • Elio Riboli, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, U.K., Storbritannien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Maria-Jose Sánchez, Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain., Spanien
  • Julie A Schmidt, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Sabina Sieri, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy., Italien
  • Anne Tjønneland, Research Diet, Genes and Environment Danish Cancer Society Research Center Strandboulevarden, Copenhagen, Denmark., Danmark
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Rosario Tumino, Cancer Registry and Histopathology Department, Civic-M.P.Arezzo Hospital, ASP, 97100 Ragusa, Italy. rtumino@tin.it., Italien
  • Roel Vermeulen, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands., Holland
  • Elisabete Weiderpass, Genetic Epidemiology Group, Folkhälsan Research Center and Faculty of Medicine, University of Helsinki, 00014 Helsinkiv, Finland. Elisabete.Weiderpass@kreftregisteret.no., Finland
  • Silvia de Sanjosé, PATH, Seattle, US., USA
  • Antonio Agudo, Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Delphine Casabonne, CIBERESP, Consortium for Biomedical Research in Epidemiology and Public Health, Spanien

The role of hormonal factors in lymphoid neoplasms etiology remains unclear. Previous studies have yielded conflicting results, been underpowered to assess many lymphoma subtypes, or lacked detailed information on relevant exposures. Within the European Prospective Investigation into Cancer and Nutrition cohort, we analyzed comprehensive data collected at baseline (1992-2000) on reproductive factors and exogenous hormone use among 343,458 women, including 1,427 incident B-cell non-Hodgkin lymphomas (NHL) and its major subtypes identified after a mean follow-up of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had a surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) compared with natural menopause (hazard ratio=1.51, 95% confidence interval=1.17, 1.94). Given that this result may be due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
Vol/bind188
Nummer2
Sider (fra-til)274-281
Antal sider8
ISSN0002-9262
DOI
StatusUdgivet - 1 feb. 2019

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