Reproductive and lifestyle factors and circulating sRANKL and OPG concentrations in women: Results from the EPIC cohort

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  • Danja Sarink, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)., Tyskland
  • Jiaxi Yang, Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., USA
  • Theron Johnson, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)., Tyskland
  • Jenny Chang-Claude, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)., Tyskland
  • Kim Overvad
  • Anja Olsen
  • Anne Tjonneland, Diet, Genes and Environment Unit, Danish Cancer Society Research Center, Copenhagen, Denmark., Danmark
  • Agnes Fournier, Health across generations team, INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Univ Paris Sud., Frankrig
  • Marina Kvaskoff, Health across Generations Team, Inserm U1018, Gustave Roussy., Frankrig
  • Francesca Romana Mancini, CESP INSERM UMRS 1018, Villejuif Cedex, France., Frankrig
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke., Tyskland
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Greece., Grækenland
  • Anna Karakatsani, 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, Hellenic Health Foundation., Grækenland
  • Elissavet Valanou, Non-profit organization, Hellenic Health Foundation., Grækenland
  • Claudia Agnoli, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Italien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Giovanna Masala, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO., Italien
  • Amalia Mattiello, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Federico II University, Naples, Italy., Italien
  • Rosario Tunino, Cancer Registry and Histopathology Department, 'Civic - M.P.Arezzo' Hospital, Italy., Italien
  • Carla H van Gils, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Holland
  • Guri Skeie, Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, N-9037 Tromsø, Norway., Norge
  • Inger T Gram, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway., Norge
  • Elisabete Weiderpass, Office of the Director, International Agency For Research On Cancer., Frankrig
  • Leila Lujan-Barroso, Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO IDIBELL)., Spanien
  • Dafina Petrova, Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Institute of Health Carlos III, Madrid, Spain; University of Granada, Center for Biomedical Research (CIBM), & Biosanitary Research Institute of Granada (ibs.GRANADA), Spain., Spanien
  • Carmen Santiuste, Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain., Spanien
  • J Ramón Quirós, Public Health Directorate., Spanien
  • Aurelio Barricarte, CIBER Epidemiologia y Salud Publica (CIBERESP)., Spanien
  • Pilar Amiano, Public Health Division of Gipuzkoa, Basque Government, Spain; Health Research Institute, Biodonostia, San Sebastián, Spain., Spanien
  • Ruth C Travis, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Marc J Gunter, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France., Frankrig
  • Laure Dossus, International Agency for Research on Cancer., Frankrig
  • Sofia Christakoudi, Department of Epidemiology and Biostatistics, Imperial College London, London, England., Storbritannien
  • Rudolf Kaaks, Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum (DKFZ)., Tyskland
  • Renée T Fortner, Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum (DKFZ) r.fortner@dkfz-heidelberg.de., Tyskland

BACKGROUND: Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor κB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women.

METHODS: This study includes 2016 controls (n=1552 (76%) postmenopausal, n=757 (38%) using postmenopausal hormone therapy (PMH)) from a breast cancer case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Serum sRANKL was measured using an enzyme-linked immunosorbent assay, serum OPG using an electrochemiluminescent assay. Generalized linear models were used to evaluate associations between these analytes and reproductive and lifestyle factors.

RESULTS: Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women (Ptrend<=0.03) and higher OPG concentrations in all women (Ptrend<=0.01). Longer duration of OC use among premenopausal women and postmenopausal PMH users was associated with higher OPG (Ptrend<=0.04). In postmenopausal non-PMH users, sRANKL concentrations were lower with longer duration of OC use and current (vs. never) smoking (P<=0.01). sRANKL concentrations were higher among women with higher BMI (Ptrend<=0.01). The evaluated factors accounted for 12% of the variation in sRANKL concentrations and 21% of the variation in OPG concentrations.

CONCLUSION: Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women.

IMPACT: This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors.

OriginalsprogEngelsk
TidsskriftCancer Epidemiology, Biomarkers & Prevention
Vol/bind28
Nummer10
Sider (fra-til)1746-1754
Antal sider9
ISSN1055-9965
DOI
StatusUdgivet - okt. 2019

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Copyright ©2019, American Association for Cancer Research.

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