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Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo. / Ulmsten, U; Andersson, K E; Forman, Axel.

I: Obstetrics and Gynecology, Bind 52, Nr. 4, 1978, s. 436-41.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Ulmsten, U, Andersson, KE & Forman, A 1978, 'Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo', Obstetrics and Gynecology, bind 52, nr. 4, s. 436-41.

APA

Ulmsten, U., Andersson, K. E., & Forman, A. (1978). Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo. Obstetrics and Gynecology, 52(4), 436-41.

CBE

Ulmsten U, Andersson KE, Forman A. 1978. Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo. Obstetrics and Gynecology. 52(4):436-41.

MLA

Ulmsten, U, K E Andersson, og Axel Forman. "Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo". Obstetrics and Gynecology. 1978, 52(4). 436-41.

Vancouver

Ulmsten U, Andersson KE, Forman A. Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo. Obstetrics and Gynecology. 1978;52(4):436-41.

Author

Ulmsten, U ; Andersson, K E ; Forman, Axel. / Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo. I: Obstetrics and Gynecology. 1978 ; Bind 52, Nr. 4. s. 436-41.

Bibtex

@article{ef22fdf5b2394163bcc627006aac258c,
title = "Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo",
abstract = "The effects of the calcium antagonist Nifedipine were investigated on isolated human myometrium and on uterine activity in healthy women during their first menstrual days. Nifedipine (0.01-1.0 microgram/ml) had a concentration-related inhibiting effect on spontaneous activity of the myometrial strips, and relaxed preparations contracted by potassium. In vivo, Nifedipine (20-30 mg) given orally, effectively and rapidly reduced uterine activity, decreasing both amplitude and frequency of uterine contractions, and reduced basal tone. A moderate increase in heart rate and a transient facial flushing were noted, but otherwise no side effects were observed. Calcium antagonists like Nifedipine represent a new approach to the problem of relaxing the myometrium, and might be an interesting therapeutic alternative in situations where inhibition of unwanted uterine activity is desirable.",
keywords = "Adult, Face, Female, Heart Rate, Humans, Menstruation, Middle Aged, Myometrium, Nifedipine, Potassium, Pyridines, Uterine Contraction, Uterus",
author = "U Ulmsten and Andersson, {K E} and Axel Forman",
year = "1978",
language = "English",
volume = "52",
pages = "436--41",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "4",

}

RIS

TY - JOUR

T1 - Relaxing effects of Nifedipine on the nonpregnant human uterus in vitro and in vivo

AU - Ulmsten, U

AU - Andersson, K E

AU - Forman, Axel

PY - 1978

Y1 - 1978

N2 - The effects of the calcium antagonist Nifedipine were investigated on isolated human myometrium and on uterine activity in healthy women during their first menstrual days. Nifedipine (0.01-1.0 microgram/ml) had a concentration-related inhibiting effect on spontaneous activity of the myometrial strips, and relaxed preparations contracted by potassium. In vivo, Nifedipine (20-30 mg) given orally, effectively and rapidly reduced uterine activity, decreasing both amplitude and frequency of uterine contractions, and reduced basal tone. A moderate increase in heart rate and a transient facial flushing were noted, but otherwise no side effects were observed. Calcium antagonists like Nifedipine represent a new approach to the problem of relaxing the myometrium, and might be an interesting therapeutic alternative in situations where inhibition of unwanted uterine activity is desirable.

AB - The effects of the calcium antagonist Nifedipine were investigated on isolated human myometrium and on uterine activity in healthy women during their first menstrual days. Nifedipine (0.01-1.0 microgram/ml) had a concentration-related inhibiting effect on spontaneous activity of the myometrial strips, and relaxed preparations contracted by potassium. In vivo, Nifedipine (20-30 mg) given orally, effectively and rapidly reduced uterine activity, decreasing both amplitude and frequency of uterine contractions, and reduced basal tone. A moderate increase in heart rate and a transient facial flushing were noted, but otherwise no side effects were observed. Calcium antagonists like Nifedipine represent a new approach to the problem of relaxing the myometrium, and might be an interesting therapeutic alternative in situations where inhibition of unwanted uterine activity is desirable.

KW - Adult

KW - Face

KW - Female

KW - Heart Rate

KW - Humans

KW - Menstruation

KW - Middle Aged

KW - Myometrium

KW - Nifedipine

KW - Potassium

KW - Pyridines

KW - Uterine Contraction

KW - Uterus

M3 - Journal article

C2 - 714325

VL - 52

SP - 436

EP - 441

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 4

ER -