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Relationship between fasting glucose, vitamin D and PTH in early postmenopausal women

Publikation: KonferencebidragPosterForskning

  • Medicinsk Endokrinologisk Afd., MEA, THG
 

Abstract

Relationship between fasting glucose, vitamin D and PTH in early postmenopausal women

Súsanna við Streym Thomsen (1), Lars Rejnmark (1), Peter Vestergaard (1), Christine Brot (2), Pia Eiken (3), Pernille Hermann (4) Leif Mosekilde (1). (1) Department of Medicine and Endocrinology C, Aarhus University Hospital, Århus Sygehus, Tage Hansens Gade 2, 8000 Århus C. Susanna.Thomsen@ki.au.dk, (2) Osteoporosis and Metabolic Bone Unit, Hvidovre Hospital, Copenhagen, Denmark, (3) Department of Cardiology and Endocrinology, Hillerød Hospital, Hillerød, Denmark, (4) Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Background: Studies have shown an increased risk of type 2 diabetes with low 25-hydroxyvitamin D (25OHD) levels.

Hypothesis: Low vitamin D is associated with a high level of blood glucose.

Aim: To investigate any association between blood glucose and 25OHD adjusted for Body Mass Index (BMI), body composition, PTH and physical activity in postmenopausal women.

Design: Cross-sectional study in postmenopausal women. 

Material and Methods: Data are based on analyses from the Danish Osteoporosis Prevention Study (DOPS), which is a cohort study in early postmenopausal Caucasian women (n=2016) aged 45 to 58 years old.

Measurements: Fasting blood glucose was measured after an overnight fast by standard laboratory methods. Serum levels of 25OHD were measured by a competitive assay using rachitic rat binding protein. The fat and lean mass was measured by DXA-scan. Serum intact parathyroid hormone was measured by DPC Immulite (chemilucens) with an inter-assay CV of 11% and an intra-assay CV of 6%. Data on physical activity was collected through a questionnaire.

Results: Results from bivariate analysis are shown in the table, indicating a significant relation between fasting blood glucose and 25OHD and all studied indices. In a multivariate linear regression analyzing fasting blood glucose was significantly associated with BMI (b=0.038 ±0.007 (SE), 2p<0.001), PHT (b=0.035 ±0.015 (SE), 2p=0.021and total physical activity (b=-0.005 ±0.002 (SE), 2p=0.036, but not with 25OHD (b=0.001 ±0.002 (SE), 2p=0.643).    

The mean and SEM for Glucose was 4.72 mmol/l (± 0.02) and 25OHD 25.1 ng/ml (± 0.3).

Conclusion: The apparent relationship between fasting blood glucose and serum 25OHD seems to be mediated by serum PTH, BMI and physical activity. As 25OHD is known to lowering PHT levels interventional trials with vitamin D supplements are warranted in order to term whether improvement of vitamin D status may improve glucose tolerance.

Table: Pearson correlation

 

 Blood Glucose25 OHDBMIFatLeanPhysical activityPTHBlood Glucose-      25 OHD-0.069xx-     BMI0.238xx-0.134xx-    Fat0.178xx-0.119xx0.920xx-   Lean0.1752xx-0.059xx0.605xx0.536xx-  Physical activity-0.653xx0.051x-0.020-0.065xx0.022- PTH 0.106xx-0.142xx  0.219xx 0.221xx0.097xx0.012-

             x = p<0,05

             xx = p<0,01

 

 

 

 

                            

 

OriginalsprogEngelsk
Udgivelsesår2010
StatusUdgivet - 2010
Begivenhed 37th European Symposium on Calcified Tissues 2010 - Glasgow, Storbritannien
Varighed: 26 jun. 201030 jun. 2010

Konference

Konference 37th European Symposium on Calcified Tissues 2010
LandStorbritannien
ByGlasgow
Periode26/06/201030/06/2010

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