Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Cancer

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During recent years, it has become clear that regulation of mRNA stability is an important event in the control of gene expression. The stability of a large class of mammalian mRNAs is regulated by AU-rich elements (AREs) located in the mRNA 3′ UTRs. mRNAs with AREs are inherently labile but as a response to different cellular cues they can become either stabilized, allowing expression of a given gene, or further destabilized to silence their expression. These tightly regulated mRNAs include many that encode growth factors, proto-oncogenes, cytokines, and cell cycle regulators. Failure to properly regulate their stability can therefore lead to uncontrolled expression of factors associated with cell proliferation and has been implicated in several human cancers. A number of transfactors that recognize AREs and regulate the translation and degradation of ARE-mRNAs have been identified. These transfactors are regulated by signal transduction pathways, which are often misregulated in cancers. This chapter focuses on the function of ARE-binding proteins with an emphasis on their regulation by signaling pathways and the implications for human cancer.
TitelRNA and Cancer
RedaktørerJane Y Wu
Antal sider28
Udgivelsesår28 feb. 2013
ISBN (trykt)978-3-642-31658-6
ISBN (Elektronisk)978-3-642-31659-3
StatusUdgivet - 28 feb. 2013
SerietitelCancer Treatment and Research

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