Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure. / Mortensen, Kim Erlend; Conley, Lene Nagsrrup; Hedegaard, Jakob; Kalstad, Trine; Sorensen, Peter; Bendixen, Christian; Revhaug, Arthur.

I: American Journal of Physiology: Gastrointestinal and Liver Physiology, Bind 294, Nr. 3, 2008, s. G818-G830.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Mortensen, KE, Conley, LN, Hedegaard, J, Kalstad, T, Sorensen, P, Bendixen, C & Revhaug, A 2008, 'Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure', American Journal of Physiology: Gastrointestinal and Liver Physiology, bind 294, nr. 3, s. G818-G830. https://doi.org/10.1152/ajpgi.00179.2007

APA

Mortensen, K. E., Conley, L. N., Hedegaard, J., Kalstad, T., Sorensen, P., Bendixen, C., & Revhaug, A. (2008). Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure. American Journal of Physiology: Gastrointestinal and Liver Physiology, 294(3), G818-G830. https://doi.org/10.1152/ajpgi.00179.2007

CBE

Mortensen KE, Conley LN, Hedegaard J, Kalstad T, Sorensen P, Bendixen C, Revhaug A. 2008. Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure. American Journal of Physiology: Gastrointestinal and Liver Physiology. 294(3):G818-G830. https://doi.org/10.1152/ajpgi.00179.2007

MLA

Mortensen, Kim Erlend o.a.. "Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure". American Journal of Physiology: Gastrointestinal and Liver Physiology. 2008, 294(3). G818-G830. https://doi.org/10.1152/ajpgi.00179.2007

Vancouver

Author

Mortensen, Kim Erlend ; Conley, Lene Nagsrrup ; Hedegaard, Jakob ; Kalstad, Trine ; Sorensen, Peter ; Bendixen, Christian ; Revhaug, Arthur. / Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure. I: American Journal of Physiology: Gastrointestinal and Liver Physiology. 2008 ; Bind 294, Nr. 3. s. G818-G830.

Bibtex

@article{812f1af009ed11dda0ff000ea68e967b,
title = "Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure",
abstract = "After parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic, and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide regulation. We aimed to investigate whether the grade of resection and hence the portal venous pressure and sinusoidal shear stress increase would be reflected in the gene expression profiles in the liver remnant by using a global porcine cDNA microarray chip with 23,000 genes represented. Six pig livers were resected with 62{\%} (low portal pressure resection) and 75{\%} (high portal pressure resection), resulting in a portal venous pressure increase from a baseline of 6.1-8.2 and 12 mmHg, respectively. By sampling consecutive biopsies from the liver remnants, we found differentially expressed genes in the high portal pressure resection group to have functions related primarily to apoptosis, nitric oxide metabolism and oxidative stress, whereas differentially expressed genes in the low portal pressure resection group potentially regulate the cell cycle. Common to both groups was the upregulation of genes regulating inflammation, transport, cell proliferation, development, and protein metabolism. Also common to both groups was both up- and downregulation of genes regulating cell-cell signaling, signal transduction, cell adhesion, and translation. Genes regulating the metabolism of lipids, hormones, amines, and alcohol were downregulated in both groups. In conclusion, the genetic regenerative response in the liver remnant to varies according to the level of resection",
keywords = "microarray, shear stress, partial hepatectomy, regeneration",
author = "Mortensen, {Kim Erlend} and Conley, {Lene Nagsrrup} and Jakob Hedegaard and Trine Kalstad and Peter Sorensen and Christian Bendixen and Arthur Revhaug",
year = "2008",
doi = "10.1152/ajpgi.00179.2007",
language = "English",
volume = "294",
pages = "G818--G830",
journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure

AU - Mortensen, Kim Erlend

AU - Conley, Lene Nagsrrup

AU - Hedegaard, Jakob

AU - Kalstad, Trine

AU - Sorensen, Peter

AU - Bendixen, Christian

AU - Revhaug, Arthur

PY - 2008

Y1 - 2008

N2 - After parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic, and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide regulation. We aimed to investigate whether the grade of resection and hence the portal venous pressure and sinusoidal shear stress increase would be reflected in the gene expression profiles in the liver remnant by using a global porcine cDNA microarray chip with 23,000 genes represented. Six pig livers were resected with 62% (low portal pressure resection) and 75% (high portal pressure resection), resulting in a portal venous pressure increase from a baseline of 6.1-8.2 and 12 mmHg, respectively. By sampling consecutive biopsies from the liver remnants, we found differentially expressed genes in the high portal pressure resection group to have functions related primarily to apoptosis, nitric oxide metabolism and oxidative stress, whereas differentially expressed genes in the low portal pressure resection group potentially regulate the cell cycle. Common to both groups was the upregulation of genes regulating inflammation, transport, cell proliferation, development, and protein metabolism. Also common to both groups was both up- and downregulation of genes regulating cell-cell signaling, signal transduction, cell adhesion, and translation. Genes regulating the metabolism of lipids, hormones, amines, and alcohol were downregulated in both groups. In conclusion, the genetic regenerative response in the liver remnant to varies according to the level of resection

AB - After parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic, and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide regulation. We aimed to investigate whether the grade of resection and hence the portal venous pressure and sinusoidal shear stress increase would be reflected in the gene expression profiles in the liver remnant by using a global porcine cDNA microarray chip with 23,000 genes represented. Six pig livers were resected with 62% (low portal pressure resection) and 75% (high portal pressure resection), resulting in a portal venous pressure increase from a baseline of 6.1-8.2 and 12 mmHg, respectively. By sampling consecutive biopsies from the liver remnants, we found differentially expressed genes in the high portal pressure resection group to have functions related primarily to apoptosis, nitric oxide metabolism and oxidative stress, whereas differentially expressed genes in the low portal pressure resection group potentially regulate the cell cycle. Common to both groups was the upregulation of genes regulating inflammation, transport, cell proliferation, development, and protein metabolism. Also common to both groups was both up- and downregulation of genes regulating cell-cell signaling, signal transduction, cell adhesion, and translation. Genes regulating the metabolism of lipids, hormones, amines, and alcohol were downregulated in both groups. In conclusion, the genetic regenerative response in the liver remnant to varies according to the level of resection

KW - microarray

KW - shear stress

KW - partial hepatectomy

KW - regeneration

U2 - 10.1152/ajpgi.00179.2007

DO - 10.1152/ajpgi.00179.2007

M3 - Journal article

C2 - 18187521

VL - 294

SP - G818-G830

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

IS - 3

ER -