Refining QTL with high-density SNP genotyping and whole genome sequence in three cattle breeds

Publikation: Bidrag til bog/antologi/rapport/proceedingKonferenceabstrakt i proceedingsForskningpeer review

Genome-wide association study was carried out in Nordic Holsteins, Nordic Red and Jersey breeds for functional traits using BovineHD Genotyping BreadChip (Illumina, San Diego, CA). The association analyses were carried out using both linear mixed model approach and a Bayesian variable selection method. Principal components were used to account for population structure. The QTL segregating in all three breeds were selected and a few of the most significant ones were followed in further analyses. The polymorphisms in the identified QTL regions were imputed using 90 whole genome sequences available from these three breeds. Imputations were done using IMPUTE v2.2. Association analyses with imputed polymorphisms were repeated for the targeted regions. The QTL genotypes of the sires with more than 20 sons were determined by an a posteriori granddaughter design. The concordance of sires for putative quantitative trait nucleotide was determined.
OriginalsprogEngelsk
TitelBook of Abstracts
Antal sider1
Vol/bind18
UdgivelsesstedThe Netherlands
ForlagWageningen Academic Publishers
Udgivelsesår27 aug. 2012
Udgave2012
Sider354
ISBN (trykt)978-90-8686-206-1
StatusUdgivet - 27 aug. 2012
Begivenhed63rd Annual Meeting EAAP 2012 - Slovak Technical University, Bratislava, Slovakiet
Varighed: 27 aug. 201231 aug. 2012
Konferencens nummer: 63

Konference

Konference63rd Annual Meeting EAAP 2012
Nummer63
LokationSlovak Technical University
LandSlovakiet
ByBratislava
Periode27/08/201231/08/2012

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