Reference interval for serum C-reactive protein in healthy blood donors using the Dade Behring N Latex CRP mono assay

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Measurement of the serum concentration of the acute-phase reactant C-reactive protein (CRP) provides an useful objective marker in clinical practice, both in screening for diseases and in monitoring disease activity and response to therapy. The aim of this study was to evaluate the analytical performance of the assay in the concentration range from 0.2 to 15 mg/L, and to determine a reference interval for serum CRP in healthy blood donors using the Dade Behring N Latex CRP mono assay on the Dade Behring Nephelometer II. The assay is a particle-enhanced nephelometric immunoassay with a measuring range of 0.2-1100 mg/L. The sample volume is 40 mu L, and the assay time is 6 min. The coefficients of variation for within-run and between-run imprecision studies were between 2.2 and 5.4% in serum pools with CRP concentrations between 1.29 and 11.98 mg/L. Linearity studies showed excellent correlation between the theoretical and the measured values. No interferences were detected from hemoglobin

OriginalsprogEngelsk
BogserieScandinavian Journal of Clinical and Laboratory Investigation. Supplement
Vol/bind60
Nummer1
Sider (fra-til)37-43
Antal sider7
ISSN0036-5513
StatusUdgivet - feb. 2000

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