Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Stefan N Hansen
  • Diana E Schendel
  • Richard W Francis, Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Australien
  • Gayle C Windham, Environmental Health Investigations Branch, California Department of Public Health, Richmond, CA, USA
  • Michaeline Bresnahan, Columbia University, Mailman School of Public Health, New York, New York State Psychiatric Institute, USA
  • Stephen Z Levine, University of Haifa, Israel
  • Abraham Reichenberg, Icahn School of Medicine at Mount Sinai, New York, NY; Seaver Autism Center for Research and Treatment at Mount Sinai, New York, USA
  • Mika Gissler, Division of Family Medicine, Karolinska Institutet, Research Centre for Child Psychiatry, University of Turku, Turku, THL National Institute for Health and Welfare, Information Services Department, Helsinki, Sverige
  • Arad Kodesh, University of Haifa, Meuhedet Health Services, Israel., Israel
  • Dan Bai, The Chinese University of Hong Kong, Hong Kong
  • Benjamin Hon Kei Yip, The Chinese University of Hong Kong, Hong Kong
  • Helen Leonard, Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Australien
  • Sven Sandin, Icahn School of Medicine at Mount Sinai, New York, NY; Seaver Autism Center for Research and Treatment at Mount Sinai, New York, Karolinska Instituttet, USA
  • Joseph D Buxbaum, Icahn School of Medicine at Mount Sinai, New York, NY; Seaver Autism Center for Research and Treatment at Mount Sinai, New York, USA
  • Christina Hultman, Karolinska Instituttet, Icahn School of Medicine at Mount Sinai, New York, NY; Seaver Autism Center for Research and Treatment at Mount Sinai, New York, Sverige
  • Andre Sourander, Turku university, Turku University Hospital, Finland
  • Emma J Glasson, Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Australien
  • Kingsley Wong, Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Australien
  • Rikard Öberg, Karolinska Institutet, Sverige
  • Erik T Parner

OBJECTIVE: Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrum disorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex.

METHOD: Population-based cohort study of 1998-2007 livebirths from California, Denmark, Finland, Israel, Sweden and Western Australia followed through 2011-2015. Subjects were monitored for an ASD diagnosis in their older siblings or cousins (exposure) and for their own ASD diagnosis (outcome). The relative recurrence risk was estimated for different sibling- and cousin-pairs, for each site separately and combined, and by sex.

RESULTS: During follow-up, 29,998 cases of ASD were observed among the 2,551,918 births used to estimate recurrence in ASD and 33,769 cases of childhood autism (CA) were observed among the 6,110,942 births used to estimate CA recurrence. Compared to the risk in unaffected families, we observed an 8.4-fold increase in the risk of ASD following an older sibling with ASD and an 17.4-fold increase in the risk of CA following an older sibling with CA. A 2-fold increase in the risk for cousin recurrence was observed for both disorders. We also found a significant difference in sibling ASD recurrence risk by sex.

CONCLUSION: Our estimates of relative recurrence risks for ASD and CA will assist clinicians and families in understanding autism risk in the context of other families in their population. The observed variation by sex underlines the need to deepen our understanding of factors influencing ASD familial risk.

OriginalsprogEngelsk
TidsskriftJournal of the American Academy of Child and Adolescent Psychiatry
Vol/bind58
Nummer9
Sider (fra-til)866-875
Antal sider10
ISSN0890-8567
DOI
StatusUdgivet - sep. 2019

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