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Recombination facilitates adaptive evolution in rhizobial soil bacteria

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Recombination facilitates adaptive evolution in rhizobial soil bacteria. / Cavassim, Maria Izabel A; Andersen, Stig U; Bataillon, Thomas; Schierup, Mikkel Heide.

I: Molecular Biology and Evolution, 19.08.2021.

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@article{f58deabfdc084adab70e5b0874616aed,
title = "Recombination facilitates adaptive evolution in rhizobial soil bacteria",
abstract = "Homologous recombination is expected to increase natural selection efficacy by decoupling the fate of beneficial and deleterious mutations and by readily creating new combinations of beneficial alleles. Here, we investigate how the proportion of amino acid substitutions fixed by adaptive evolution (α) depends on the recombination rate in bacteria. We analyze 3086 core protein-coding sequences from 196 genomes belonging to five closely related species of the genus Rhizobium. These genes are found in all species and do not display any signs of introgression between species. We estimate α using the site frequency spectrum (SFS) and divergence data for all pairs of species. We evaluate the impact of recombination within each species by dividing genes into three equally sized recombination classes based on their average level of intragenic linkage disequilibrium. We find that α varies from 0.07 to 0.39 across species and is positively correlated with the level of recombination. This is both due to a higher estimated rate of adaptive evolution and a lower estimated rate of non-adaptive evolution, suggesting that recombination both increases the fixation probability of advantageous variants and decreases the probability of fixation of deleterious variants. Our results demonstrate that homologous recombination facilitates adaptive evolution measured by α in the core genome of prokaryote species in agreement with studies in eukaryotes.",
author = "Cavassim, {Maria Izabel A} and Andersen, {Stig U} and Thomas Bataillon and Schierup, {Mikkel Heide}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.",
year = "2021",
month = aug,
day = "19",
doi = "10.1093/molbev/msab247",
language = "English",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Recombination facilitates adaptive evolution in rhizobial soil bacteria

AU - Cavassim, Maria Izabel A

AU - Andersen, Stig U

AU - Bataillon, Thomas

AU - Schierup, Mikkel Heide

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

PY - 2021/8/19

Y1 - 2021/8/19

N2 - Homologous recombination is expected to increase natural selection efficacy by decoupling the fate of beneficial and deleterious mutations and by readily creating new combinations of beneficial alleles. Here, we investigate how the proportion of amino acid substitutions fixed by adaptive evolution (α) depends on the recombination rate in bacteria. We analyze 3086 core protein-coding sequences from 196 genomes belonging to five closely related species of the genus Rhizobium. These genes are found in all species and do not display any signs of introgression between species. We estimate α using the site frequency spectrum (SFS) and divergence data for all pairs of species. We evaluate the impact of recombination within each species by dividing genes into three equally sized recombination classes based on their average level of intragenic linkage disequilibrium. We find that α varies from 0.07 to 0.39 across species and is positively correlated with the level of recombination. This is both due to a higher estimated rate of adaptive evolution and a lower estimated rate of non-adaptive evolution, suggesting that recombination both increases the fixation probability of advantageous variants and decreases the probability of fixation of deleterious variants. Our results demonstrate that homologous recombination facilitates adaptive evolution measured by α in the core genome of prokaryote species in agreement with studies in eukaryotes.

AB - Homologous recombination is expected to increase natural selection efficacy by decoupling the fate of beneficial and deleterious mutations and by readily creating new combinations of beneficial alleles. Here, we investigate how the proportion of amino acid substitutions fixed by adaptive evolution (α) depends on the recombination rate in bacteria. We analyze 3086 core protein-coding sequences from 196 genomes belonging to five closely related species of the genus Rhizobium. These genes are found in all species and do not display any signs of introgression between species. We estimate α using the site frequency spectrum (SFS) and divergence data for all pairs of species. We evaluate the impact of recombination within each species by dividing genes into three equally sized recombination classes based on their average level of intragenic linkage disequilibrium. We find that α varies from 0.07 to 0.39 across species and is positively correlated with the level of recombination. This is both due to a higher estimated rate of adaptive evolution and a lower estimated rate of non-adaptive evolution, suggesting that recombination both increases the fixation probability of advantageous variants and decreases the probability of fixation of deleterious variants. Our results demonstrate that homologous recombination facilitates adaptive evolution measured by α in the core genome of prokaryote species in agreement with studies in eukaryotes.

U2 - 10.1093/molbev/msab247

DO - 10.1093/molbev/msab247

M3 - Journal article

C2 - 34410427

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

ER -