Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids

Daniela Grimm; Thomas J Corydon; Jayashree Sahana; Luis Fernando González-Torres; Armin Kraus; Shannon Marchal; Petra M Wise; Ulf Simonsen; Marcus Krüger

doi:10.1093/stcltm/szaf008

Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids

Daniela Grimm, Thomas J Corydon, Jayashree Sahana, Luis Fernando González-Torres, Armin Kraus, Shannon Marchal, Petra M Wise, Ulf Simonsen, Marcus Krüger

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

1 Citationer (Scopus)

Abstract

The still young and developing space age, characterized by lunar and Martian exploration and the vision of extraterrestrial settlements, presents a unique environment to study the impact of microgravity (µg) on human physiology and disease development. Cancer research is currently a key focus of international space science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth of cancer cells as well as the cytoskeleton and the extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in a µg-environment, like multicellular spheroids (MCS), researchers can expedite drug discovery and development, reducing the need for animal testing. This concise review analyses the latest knowledge on the influence of µg on cancer cells and MCS formation. We will focus on cells from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, and skin cancer exposed to real (r-) and simulated (s-) µg-conditions.

Originalsprog	Engelsk
Artikelnummer	szaf008
Tidsskrift	Stem Cells Translational Medicine
Vol/bind	14
Nummer	3
ISSN	2157-6564
DOI	https://doi.org/10.1093/stcltm/szaf008
Status	Udgivet - 1 mar. 2025

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abstract = "The still young and developing space age, characterized by lunar and Martian exploration and the vision of extraterrestrial settlements, presents a unique environment to study the impact of microgravity (µg) on human physiology and disease development. Cancer research is currently a key focus of international space science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth of cancer cells as well as the cytoskeleton and the extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in a µg-environment, like multicellular spheroids (MCS), researchers can expedite drug discovery and development, reducing the need for animal testing. This concise review analyses the latest knowledge on the influence of µg on cancer cells and MCS formation. We will focus on cells from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, and skin cancer exposed to real (r-) and simulated (s-) µg-conditions.",

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Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids. / Grimm, Daniela ; Corydon, Thomas J ; Sahana, Jayashree et al.
I: Stem Cells Translational Medicine, Bind 14, Nr. 3, szaf008, 01.03.2025.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

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AU - Grimm, Daniela

AU - Corydon, Thomas J

AU - Sahana, Jayashree

AU - González-Torres, Luis Fernando

AU - Kraus, Armin

AU - Marchal, Shannon

AU - Wise, Petra M

AU - Simonsen, Ulf

AU - Krüger, Marcus

N1 - © The Author(s) 2025. Published by Oxford University Press.

PY - 2025/3/1

Y1 - 2025/3/1

N2 - The still young and developing space age, characterized by lunar and Martian exploration and the vision of extraterrestrial settlements, presents a unique environment to study the impact of microgravity (µg) on human physiology and disease development. Cancer research is currently a key focus of international space science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth of cancer cells as well as the cytoskeleton and the extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in a µg-environment, like multicellular spheroids (MCS), researchers can expedite drug discovery and development, reducing the need for animal testing. This concise review analyses the latest knowledge on the influence of µg on cancer cells and MCS formation. We will focus on cells from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, and skin cancer exposed to real (r-) and simulated (s-) µg-conditions.

AB - The still young and developing space age, characterized by lunar and Martian exploration and the vision of extraterrestrial settlements, presents a unique environment to study the impact of microgravity (µg) on human physiology and disease development. Cancer research is currently a key focus of international space science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth of cancer cells as well as the cytoskeleton and the extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in a µg-environment, like multicellular spheroids (MCS), researchers can expedite drug discovery and development, reducing the need for animal testing. This concise review analyses the latest knowledge on the influence of µg on cancer cells and MCS formation. We will focus on cells from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, and skin cancer exposed to real (r-) and simulated (s-) µg-conditions.

KW - cancer

KW - cancer stem cells

KW - in vitro metastasis

KW - microgravity

KW - space biotechnology

KW - tumor spheroids

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Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids

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