Recent progress in miRNA biogenesis and decay

Xavier Bofill-De Ros*, Ulf Andersson Vang Ørom*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

32 Citationer (Scopus)

Abstract

MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.

OriginalsprogEngelsk
TidsskriftRNA Biology
Vol/bind21
Nummer1
Sider (fra-til)1-8
Antal sider8
ISSN1547-6286
DOI
StatusUdgivet - 2024

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