Recent progress in miRNA biogenesis and decay

Xavier Bofill-De Ros; Ulf Andersson Vang Ørom

doi:10.1080/15476286.2023.2288741

Recent progress in miRNA biogenesis and decay

Xavier Bofill-De Ros^*, Ulf Andersson Vang Ørom^*

^*Corresponding author af dette arbejde

Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

38 Citationer (Scopus)

Abstract

MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.

Originalsprog	Engelsk
Tidsskrift	RNA Biology
Vol/bind	21
Nummer	1
Sider (fra-til)	1-8
Antal sider	8
ISSN	1547-6286
DOI	https://doi.org/10.1080/15476286.2023.2288741
Status	Udgivet - 2024

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10.1080/15476286.2023.2288741Licens: CC BY-NC

Citationsformater

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abstract = "MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.",

keywords = "miRNA biogenesis, miRNA decay, miRNA stability, miRNA targeting, miRNA therapeutics",

author = "{Bofill-De Ros}, Xavier and {Vang {\O}rom}, {Ulf Andersson}",

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T1 - Recent progress in miRNA biogenesis and decay

AU - Bofill-De Ros, Xavier

AU - Vang Ørom, Ulf Andersson

PY - 2024

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AB - MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.

KW - miRNA biogenesis

KW - miRNA decay

KW - miRNA stability

KW - miRNA targeting

KW - miRNA therapeutics

U2 - 10.1080/15476286.2023.2288741

DO - 10.1080/15476286.2023.2288741

M3 - Review

C2 - 38031325

AN - SCOPUS:85178231314

SN - 1547-6286

VL - 21

SP - 1

EP - 8

JO - RNA Biology

JF - RNA Biology

IS - 1

ER -

Recent progress in miRNA biogenesis and decay

Abstract

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