Recent developments in the use of peroxygenases – Exploring their high potential in selective oxyfunctionalisations

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  • Markus Hobisch
  • Dirk Holtmann, University of Applied Sciences Mittelhessen
  • ,
  • Patricia Gomes de Santos, Institute of Catalysis, CSIC
  • ,
  • Miguel Alcalde, CSIC, Madrid, EvoEnzyme S.L,
  • Frank Hollmann, Department of Biotechnology, Delft University of Technology, Delft
  • ,
  • Selin Kara

Peroxygenases are an emerging new class of enzymes allowing selective oxyfunctionalisation reactions in a cofactor-independent way different from well-known P450 monooxygenases. Herein, we focused on recent developments from organic synthesis, molecular biotechnology and reaction engineering viewpoints that are devoted to bring these enzymes in industrial applications. This covers natural diversity from different sources, protein engineering strategies for expression, substrate scope, activity and selectivity, stabilisation of enzymes via immobilisation, and the use of peroxygenases in low water media. We believe that peroxygenases have much to offer for selective oxyfunctionalisations and we have much to study to explore the full potential of these versatile biocatalysts in organic synthesis.

TidsskriftBiotechnology Advances
Antal sider13
StatusAccepteret/In press - 19 aug. 2020

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