Recent Advancements in Using Polymers for Intestinal Mucoadhesion and Mucopenetration

Essi Taipaleenmäki, Brigitte Städler*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Abstract

Oral administration of actives is the most desired form of delivery, but the formulations need to overcome a variety of barriers including the intestinal mucus. This feature article summarizes the developments from the past 2–3 years in this context focusing on polymer-based formulations. The progress in assembling mucopenetrating nanoparticles is outlined considering coatings using noninteracting polymers as well as virus-like particles and charge-shifting particles. Next, polymers and their modification to enhance mucoadhesion are discussed, followed by providing examples of double-encapsulation systems that aim to combine mucopenetration with mucoadhesion in the same formulation. Finally, a short outlook is provided highlighting a few of the most pressing challenges to address.

OriginalsprogEngelsk
Artikelnummer1900342
TidsskriftMacromolecular Bioscience
Vol/bind20
Nummer3
Antal sider9
ISSN1616-5187
DOI
StatusUdgivet - 2020

Fingeraftryk

Dyk ned i forskningsemnerne om 'Recent Advancements in Using Polymers for Intestinal Mucoadhesion and Mucopenetration'. Sammen danner de et unikt fingeraftryk.

Citationsformater