Real-time intrafraction motion monitoring in external beam radiotherapy

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Standard

Real-time intrafraction motion monitoring in external beam radiotherapy. / Bertholet, Jenny; Knopf, Antje; Eiben, Bjorn; McClelland, Jamie; Grimwood, Alexander; Harris, Emma; Menten, Martin; Poulsen, Per; Doan Trang Nguyen; Keall, Paul; Oelfke, Uwe.

I: Physics in Medicine and Biology, Bind 64, Nr. 15, 15TR01, 08.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Harvard

Bertholet, J, Knopf, A, Eiben, B, McClelland, J, Grimwood, A, Harris, E, Menten, M, Poulsen, P, Doan Trang Nguyen, Keall, P & Oelfke, U 2019, 'Real-time intrafraction motion monitoring in external beam radiotherapy', Physics in Medicine and Biology, bind 64, nr. 15, 15TR01. https://doi.org/10.1088/1361-6560/ab2ba8

APA

Bertholet, J., Knopf, A., Eiben, B., McClelland, J., Grimwood, A., Harris, E., Menten, M., Poulsen, P., Doan Trang Nguyen, Keall, P., & Oelfke, U. (2019). Real-time intrafraction motion monitoring in external beam radiotherapy. Physics in Medicine and Biology, 64(15), [15TR01]. https://doi.org/10.1088/1361-6560/ab2ba8

CBE

Bertholet J, Knopf A, Eiben B, McClelland J, Grimwood A, Harris E, Menten M, Poulsen P, Doan Trang Nguyen, Keall P, Oelfke U. 2019. Real-time intrafraction motion monitoring in external beam radiotherapy. Physics in Medicine and Biology. 64(15):Article 15TR01. https://doi.org/10.1088/1361-6560/ab2ba8

MLA

Vancouver

Bertholet J, Knopf A, Eiben B, McClelland J, Grimwood A, Harris E o.a. Real-time intrafraction motion monitoring in external beam radiotherapy. Physics in Medicine and Biology. 2019 aug;64(15). 15TR01. https://doi.org/10.1088/1361-6560/ab2ba8

Author

Bertholet, Jenny ; Knopf, Antje ; Eiben, Bjorn ; McClelland, Jamie ; Grimwood, Alexander ; Harris, Emma ; Menten, Martin ; Poulsen, Per ; Doan Trang Nguyen ; Keall, Paul ; Oelfke, Uwe. / Real-time intrafraction motion monitoring in external beam radiotherapy. I: Physics in Medicine and Biology. 2019 ; Bind 64, Nr. 15.

Bibtex

@article{7b00a64efdf24c0ca067da55afab2fb2,
title = "Real-time intrafraction motion monitoring in external beam radiotherapy",
abstract = "Radiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is constantly moving due to respiratory, cardiac, gastrointestinal and urinary activity. The long term goal of the RT community to 'see what we treat, as we treat' and to act on this information instantaneously has resulted in rapid technological innovation. Specialized treatment machines, such as robotic or gimbal-steered linear accelerators (linac) with in-room imaging suites, have been developed specifically for real-time treatment adaptation. Additional equipment, such as stereoscopic kilovoltage (kV) imaging, ultrasound transducers and electromagnetic transponders, has been developed for intrafraction motion monitoring on conventional linacs. Magnetic resonance imaging (MRI) has been integrated with cobalt treatment units and more recently with linacs. In addition to hardware innovation, software development has played a substantial role in the development of motion monitoring methods based on respiratory motion surrogates and planar kV or Megavoltage (MV) imaging that is available on standard equipped linacs.In this paper, we review and compare the different intrafraction motion monitoring methods proposed in the literature and demonstrated in real-time on clinical data as well as their possible future developments. We then discuss general considerations on validation and quality assurance for clinical implementation.Besides photon RT, particle therapy is increasingly used to treat moving targets. However, transferring motion monitoring technologies from linacs to particle beam lines presents substantial challenges. Lessons learned from the implementation of real-time intrafraction monitoring for photon RT will be used as a basis to discuss the implementation of these methods for particle RT.",
keywords = "motion monitoring, IGRT, MR-guided RT, tumour motion, particle therapy, ultrasound imaging, tracking, IMAGE-GUIDED RADIOTHERAPY, BODY RADIATION-THERAPY, INSPIRATION BREATH-HOLD, TUMOR-TRACKING RADIOTHERAPY, IMPLANTED FIDUCIAL MARKERS, TREATMENT-COUCH TRACKING, MODULATED ARC THERAPY, STEREOTACTIC ABLATIVE RADIOTHERAPY, LEAF COLLIMATOR TRACKING, GIMBALED LINAC SYSTEM",
author = "Jenny Bertholet and Antje Knopf and Bjorn Eiben and Jamie McClelland and Alexander Grimwood and Emma Harris and Martin Menten and Per Poulsen and {Doan Trang Nguyen} and Paul Keall and Uwe Oelfke",
year = "2019",
month = aug,
doi = "10.1088/1361-6560/ab2ba8",
language = "English",
volume = "64",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "Institute of Physics Publishing Ltd.",
number = "15",

}

RIS

TY - JOUR

T1 - Real-time intrafraction motion monitoring in external beam radiotherapy

AU - Bertholet, Jenny

AU - Knopf, Antje

AU - Eiben, Bjorn

AU - McClelland, Jamie

AU - Grimwood, Alexander

AU - Harris, Emma

AU - Menten, Martin

AU - Poulsen, Per

AU - Doan Trang Nguyen, null

AU - Keall, Paul

AU - Oelfke, Uwe

PY - 2019/8

Y1 - 2019/8

N2 - Radiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is constantly moving due to respiratory, cardiac, gastrointestinal and urinary activity. The long term goal of the RT community to 'see what we treat, as we treat' and to act on this information instantaneously has resulted in rapid technological innovation. Specialized treatment machines, such as robotic or gimbal-steered linear accelerators (linac) with in-room imaging suites, have been developed specifically for real-time treatment adaptation. Additional equipment, such as stereoscopic kilovoltage (kV) imaging, ultrasound transducers and electromagnetic transponders, has been developed for intrafraction motion monitoring on conventional linacs. Magnetic resonance imaging (MRI) has been integrated with cobalt treatment units and more recently with linacs. In addition to hardware innovation, software development has played a substantial role in the development of motion monitoring methods based on respiratory motion surrogates and planar kV or Megavoltage (MV) imaging that is available on standard equipped linacs.In this paper, we review and compare the different intrafraction motion monitoring methods proposed in the literature and demonstrated in real-time on clinical data as well as their possible future developments. We then discuss general considerations on validation and quality assurance for clinical implementation.Besides photon RT, particle therapy is increasingly used to treat moving targets. However, transferring motion monitoring technologies from linacs to particle beam lines presents substantial challenges. Lessons learned from the implementation of real-time intrafraction monitoring for photon RT will be used as a basis to discuss the implementation of these methods for particle RT.

AB - Radiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is constantly moving due to respiratory, cardiac, gastrointestinal and urinary activity. The long term goal of the RT community to 'see what we treat, as we treat' and to act on this information instantaneously has resulted in rapid technological innovation. Specialized treatment machines, such as robotic or gimbal-steered linear accelerators (linac) with in-room imaging suites, have been developed specifically for real-time treatment adaptation. Additional equipment, such as stereoscopic kilovoltage (kV) imaging, ultrasound transducers and electromagnetic transponders, has been developed for intrafraction motion monitoring on conventional linacs. Magnetic resonance imaging (MRI) has been integrated with cobalt treatment units and more recently with linacs. In addition to hardware innovation, software development has played a substantial role in the development of motion monitoring methods based on respiratory motion surrogates and planar kV or Megavoltage (MV) imaging that is available on standard equipped linacs.In this paper, we review and compare the different intrafraction motion monitoring methods proposed in the literature and demonstrated in real-time on clinical data as well as their possible future developments. We then discuss general considerations on validation and quality assurance for clinical implementation.Besides photon RT, particle therapy is increasingly used to treat moving targets. However, transferring motion monitoring technologies from linacs to particle beam lines presents substantial challenges. Lessons learned from the implementation of real-time intrafraction monitoring for photon RT will be used as a basis to discuss the implementation of these methods for particle RT.

KW - motion monitoring

KW - IGRT

KW - MR-guided RT

KW - tumour motion

KW - particle therapy

KW - ultrasound imaging

KW - tracking

KW - IMAGE-GUIDED RADIOTHERAPY

KW - BODY RADIATION-THERAPY

KW - INSPIRATION BREATH-HOLD

KW - TUMOR-TRACKING RADIOTHERAPY

KW - IMPLANTED FIDUCIAL MARKERS

KW - TREATMENT-COUCH TRACKING

KW - MODULATED ARC THERAPY

KW - STEREOTACTIC ABLATIVE RADIOTHERAPY

KW - LEAF COLLIMATOR TRACKING

KW - GIMBALED LINAC SYSTEM

U2 - 10.1088/1361-6560/ab2ba8

DO - 10.1088/1361-6560/ab2ba8

M3 - Review

C2 - 31226704

VL - 64

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 15

M1 - 15TR01

ER -