Quaternary Ammoniumyl Chitosan Derivatives for Eradication of Staphylococcus aureus Biofilms

Priyanka Sahariah*, Mar Masson, Rikke Louise Meyer

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Abstract

Bacterial biofilms tolerate extreme levels of antibiotics. Treatment of biofilm infections therefore requires the development of new or modified antimicrobials that can penetrate biofilms and are effective against dormant persistent cells. One such new approach uses the biodegradable biopolymer chitosan and its derivatives as antimicrobials. In this study, we performed synthetic modification of chitosan to selectively introduce different cationic and hydrophobic moieties at varying ratios on chitosan. This improved its aqueous solubility and antimicrobial activity toward bacterial biofilms. Initial evaluation of the chitosan derivatives showed increased activity toward planktonic Staphylococcus aureus. The effect of the quaternary ammoniumyl chitosan derivatives against Staphylococcus aureus biofilms was more variable. The most effective derivatives contained hydrophobic groups, and their efficacy against biofilms depended on the ratio and length of the alkyl chains. Three-dimensional imaging of biofilms confirmed the accessibility and antimicrobial effect of chitosan derivatives with alkyl chains in the full depth of the biofilms.

OriginalsprogEngelsk
TidsskriftBiomacromolecules
Vol/bind19
Nummer9
Sider (fra-til)3649-3658
Antal sider10
ISSN1525-7797
DOI
StatusUdgivet - sep. 2018

Fingeraftryk

Dyk ned i forskningsemnerne om 'Quaternary Ammoniumyl Chitosan Derivatives for Eradication of Staphylococcus aureus Biofilms'. Sammen danner de et unikt fingeraftryk.

Citationsformater