Quantum dot-based nanosensors for diagnosis via enzyme activity measurement

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

  • Birgitta R Knudsen
  • Morten Leth Jepsen, Interdisciplinary Nanoscience Center, Aarhus University
  • ,
  • Yi-Ping Ho, Danmark
Enzymes are essential in the human body, and the disorder of enzymatic activities has been associated with many different diseases and stages of disease. Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have garnered great attention in molecular diagnostics. Owing to their superior optical properties, tunable and narrow emissions, stable brightness and long lifetime, QD-based enzyme activity measurement has demonstrated improved detection sensitivity, which is considered particularly valuable for early disease diagnosis. Recent studies have also shown that QD-based nanosensors are capable of probing multiple enzyme activities simultaneously. This review highlights the current development of QD-based nanosensors for enzyme detection. The enzyme-QD hybrid system, equipped with unique electronic, optical and catalytic properties, is envisioned as a potential solution in addressing challenges in diagnostics and therapeutics.
OriginalsprogEngelsk
TidsskriftExpert Review of Molecular Diagnostics
Vol/bind13
Nummer4
Sider (fra-til)367-375
Antal sider9
ISSN1473-7159
DOI
StatusUdgivet - maj 2013

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