Quality of life with or without sphincter preservation for rectal cancer

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Quality of life with or without sphincter preservation for rectal cancer. / Feddern, M. L.; Emmertsen, K. J.; Laurberg, S.

I: Colorectal Disease, Bind 21, Nr. 9, 01.09.2019, s. 1051-1057.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Feddern, M. L. ; Emmertsen, K. J. ; Laurberg, S. / Quality of life with or without sphincter preservation for rectal cancer. I: Colorectal Disease. 2019 ; Bind 21, Nr. 9. s. 1051-1057.

Bibtex

@article{05b0b07b21bf435ba885145fb2bff78c,
title = "Quality of life with or without sphincter preservation for rectal cancer",
abstract = "Aim: The aim of this investigation was to examine quality of life after surgical treatment for low rectal cancer. Method: This was a population-based, cross-sectional study on quality of life in patients treated for rectal cancer from 2001 to 2007. The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) and a single question on the impact of bowel/stoma function on quality of life were sent to patients who had undergone abdominoperineal excision (APE) or low anterior resection (LAR) for rectal cancer with tumours below 10 cm from the anal verge. Results: Informative answers were obtained from 898 patients (87{\%}). EORTC QLQ-C30 outcomes were very similar for APE and LAR patients in univariate analysis. When adjusted for neoadjuvant radiotherapy and gender, multivariate analysis showed that LAR patients had lower global health status (OR 1.32, 95{\%} CI 1.03; 1.68, P = 0.026) and higher occurrence of constipation (OR 0.47, 95{\%} CI 0.32; 0.69, P < 0.001) and diarrhoea (OR 0.47, 95{\%} CI 0.35; 0.64, P < 0.001). Analysis of the anchor question showed that LAR patients had significantly higher negative impact of bowel function on quality of life in both univariate (OR 3.38, 95{\%} CI 2.62; 4.37, P < 0.001) and multivariate analysis (OR 3.71, 95{\%} CI 2.86; 4.83, P < 0.001) compared with APE. Conclusion: For patients with low rectal cancer, we found LAR patients had worse global health status and problems with diarrhoea and constipation compared with APE patients.",
keywords = "quality of life, Rectal cancer, surgery",
author = "Feddern, {M. L.} and Emmertsen, {K. J.} and S. Laurberg",
year = "2019",
month = "9",
day = "1",
doi = "10.1111/codi.14684",
language = "English",
volume = "21",
pages = "1051--1057",
journal = "Colorectal Disease",
issn = "1462-8910",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Quality of life with or without sphincter preservation for rectal cancer

AU - Feddern, M. L.

AU - Emmertsen, K. J.

AU - Laurberg, S.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Aim: The aim of this investigation was to examine quality of life after surgical treatment for low rectal cancer. Method: This was a population-based, cross-sectional study on quality of life in patients treated for rectal cancer from 2001 to 2007. The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) and a single question on the impact of bowel/stoma function on quality of life were sent to patients who had undergone abdominoperineal excision (APE) or low anterior resection (LAR) for rectal cancer with tumours below 10 cm from the anal verge. Results: Informative answers were obtained from 898 patients (87%). EORTC QLQ-C30 outcomes were very similar for APE and LAR patients in univariate analysis. When adjusted for neoadjuvant radiotherapy and gender, multivariate analysis showed that LAR patients had lower global health status (OR 1.32, 95% CI 1.03; 1.68, P = 0.026) and higher occurrence of constipation (OR 0.47, 95% CI 0.32; 0.69, P < 0.001) and diarrhoea (OR 0.47, 95% CI 0.35; 0.64, P < 0.001). Analysis of the anchor question showed that LAR patients had significantly higher negative impact of bowel function on quality of life in both univariate (OR 3.38, 95% CI 2.62; 4.37, P < 0.001) and multivariate analysis (OR 3.71, 95% CI 2.86; 4.83, P < 0.001) compared with APE. Conclusion: For patients with low rectal cancer, we found LAR patients had worse global health status and problems with diarrhoea and constipation compared with APE patients.

AB - Aim: The aim of this investigation was to examine quality of life after surgical treatment for low rectal cancer. Method: This was a population-based, cross-sectional study on quality of life in patients treated for rectal cancer from 2001 to 2007. The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) and a single question on the impact of bowel/stoma function on quality of life were sent to patients who had undergone abdominoperineal excision (APE) or low anterior resection (LAR) for rectal cancer with tumours below 10 cm from the anal verge. Results: Informative answers were obtained from 898 patients (87%). EORTC QLQ-C30 outcomes were very similar for APE and LAR patients in univariate analysis. When adjusted for neoadjuvant radiotherapy and gender, multivariate analysis showed that LAR patients had lower global health status (OR 1.32, 95% CI 1.03; 1.68, P = 0.026) and higher occurrence of constipation (OR 0.47, 95% CI 0.32; 0.69, P < 0.001) and diarrhoea (OR 0.47, 95% CI 0.35; 0.64, P < 0.001). Analysis of the anchor question showed that LAR patients had significantly higher negative impact of bowel function on quality of life in both univariate (OR 3.38, 95% CI 2.62; 4.37, P < 0.001) and multivariate analysis (OR 3.71, 95% CI 2.86; 4.83, P < 0.001) compared with APE. Conclusion: For patients with low rectal cancer, we found LAR patients had worse global health status and problems with diarrhoea and constipation compared with APE patients.

KW - quality of life

KW - Rectal cancer

KW - surgery

UR - http://www.scopus.com/inward/record.url?scp=85067395163&partnerID=8YFLogxK

U2 - 10.1111/codi.14684

DO - 10.1111/codi.14684

M3 - Journal article

VL - 21

SP - 1051

EP - 1057

JO - Colorectal Disease

JF - Colorectal Disease

SN - 1462-8910

IS - 9

ER -