Quality of life in pediatric patients with obsessive–compulsive disorder during and 3 years after stepped-care treatment

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Standard

Quality of life in pediatric patients with obsessive–compulsive disorder during and 3 years after stepped-care treatment. / Jensen, Sanne; Hybel, Katja A.; Højgaard, Davíð R.M.A. et al.

I: European Child and Adolescent Psychiatry, Bind 31, Nr. 9, 09.2022, s. 1377-1389.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Jensen, S, Hybel, KA, Højgaard, DRMA, Nissen, JB, Weidle, B, Ivarsson, T, Skarphedinsson, G, Melin, K, Torp, NC, Carlsen, AH, Mortensen, EL, Lenhard, F, Compton, S & Thomsen, PH 2022, 'Quality of life in pediatric patients with obsessive–compulsive disorder during and 3 years after stepped-care treatment', European Child and Adolescent Psychiatry, bind 31, nr. 9, s. 1377-1389. https://doi.org/10.1007/s00787-021-01775-w

APA

Jensen, S., Hybel, K. A., Højgaard, D. R. M. A., Nissen, J. B., Weidle, B., Ivarsson, T., Skarphedinsson, G., Melin, K., Torp, N. C., Carlsen, A. H., Mortensen, E. L., Lenhard, F., Compton, S., & Thomsen, P. H. (2022). Quality of life in pediatric patients with obsessive–compulsive disorder during and 3 years after stepped-care treatment. European Child and Adolescent Psychiatry, 31(9), 1377-1389. https://doi.org/10.1007/s00787-021-01775-w

CBE

Jensen S, Hybel KA, Højgaard DRMA, Nissen JB, Weidle B, Ivarsson T, Skarphedinsson G, Melin K, Torp NC, Carlsen AH, et al. 2022. Quality of life in pediatric patients with obsessive–compulsive disorder during and 3 years after stepped-care treatment. European Child and Adolescent Psychiatry. 31(9):1377-1389. https://doi.org/10.1007/s00787-021-01775-w

MLA

Vancouver

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Bibtex

@article{83445ff435a34e0d86a8253d20ea5ed5,
title = "Quality of life in pediatric patients with obsessive–compulsive disorder during and 3 years after stepped-care treatment",
abstract = "The present study aimed to investigate the long-term quality of life (QoL) in a large sample of pediatric obsessive–compulsive disorder (OCD) patients. The study included 220 pediatric OCD patients from the Nordic Long-term OCD Treatment Study (NordLOTS) who were evaluated at seven time points before, during, and after stepped-care treatment over a 3-year follow-up period. Data from three symptom severity trajectory classes formed the basis of the QoL evaluation: acute (n = 127, N = 147), slow (n = 46, N = 63), and limited responders (n = 47, N = 59). Patients{\textquoteright} QoL was assessed using parent and child ratings of the revised Questionnaire for Measuring Health-related Quality of Life in Children and Adolescents (KINDL-R). QoL was analyzed by trajectory class using a random mixed effects model. The association between pre-treatment factors and long-term QoL was investigated across classes in a multivariate model. Three years after treatment, the acute responder class had reached QoL levels from a general population, whereas the limited responder class had not. The slow responder class reached norm levels for the child-rated QoL only. Higher levels of co-occurring externalizing symptoms before treatment were associated with lower parent-rated QoL during follow-up, while adolescence and higher levels of co-occurring internalizing symptoms were associated with lower child-rated QoL during follow-up. For some patients, residual OCD symptoms in the years after treatment, even at levels below assumed clinical significance, are associated with compromised QoL. Co-occurring symptoms could be part of the explanation. Assessing QoL after OCD treatment, beyond the clinician-rated symptom severity, could detect patients in need of further treatment and/or assessment. Trial registry: Nordic Long-term Obsessive–Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119.",
keywords = "Children and adolescents, Long-term, Obsessive–compulsive disorder, Quality of life, Stepped-care treatment, Treatment outcome, PSYCHOMETRIC PROPERTIES, FUNCTIONAL IMPAIRMENT, SYMPTOMS, SCHOOL-CHILDREN, MENTAL-HEALTH, TERM OCD TREATMENT, ADOLESCENTS, COGNITIVE-BEHAVIOR THERAPY, GLOBAL ASSESSMENT SCALE, Obsessive-compulsive disorder, QUESTIONNAIRE",
author = "Sanne Jensen and Hybel, {Katja A.} and H{\o}jgaard, {Dav{\'i}{\dh} R.M.A.} and Nissen, {Judith Becker} and Bernhard Weidle and Tord Ivarsson and Gudmundur Skarphedinsson and Karin Melin and Torp, {Nor Christian} and Carlsen, {Anders Helles} and Mortensen, {Erik Lykke} and Fabian Lenhard and Scott Compton and Thomsen, {Per Hove}",
year = "2022",
month = sep,
doi = "10.1007/s00787-021-01775-w",
language = "English",
volume = "31",
pages = "1377--1389",
journal = "European Child & Adolescent Psychiatry",
issn = "1018-8827",
publisher = "Springer Medizin",
number = "9",

}

RIS

TY - JOUR

T1 - Quality of life in pediatric patients with obsessive–compulsive disorder during and 3 years after stepped-care treatment

AU - Jensen, Sanne

AU - Hybel, Katja A.

AU - Højgaard, Davíð R.M.A.

AU - Nissen, Judith Becker

AU - Weidle, Bernhard

AU - Ivarsson, Tord

AU - Skarphedinsson, Gudmundur

AU - Melin, Karin

AU - Torp, Nor Christian

AU - Carlsen, Anders Helles

AU - Mortensen, Erik Lykke

AU - Lenhard, Fabian

AU - Compton, Scott

AU - Thomsen, Per Hove

PY - 2022/9

Y1 - 2022/9

N2 - The present study aimed to investigate the long-term quality of life (QoL) in a large sample of pediatric obsessive–compulsive disorder (OCD) patients. The study included 220 pediatric OCD patients from the Nordic Long-term OCD Treatment Study (NordLOTS) who were evaluated at seven time points before, during, and after stepped-care treatment over a 3-year follow-up period. Data from three symptom severity trajectory classes formed the basis of the QoL evaluation: acute (n = 127, N = 147), slow (n = 46, N = 63), and limited responders (n = 47, N = 59). Patients’ QoL was assessed using parent and child ratings of the revised Questionnaire for Measuring Health-related Quality of Life in Children and Adolescents (KINDL-R). QoL was analyzed by trajectory class using a random mixed effects model. The association between pre-treatment factors and long-term QoL was investigated across classes in a multivariate model. Three years after treatment, the acute responder class had reached QoL levels from a general population, whereas the limited responder class had not. The slow responder class reached norm levels for the child-rated QoL only. Higher levels of co-occurring externalizing symptoms before treatment were associated with lower parent-rated QoL during follow-up, while adolescence and higher levels of co-occurring internalizing symptoms were associated with lower child-rated QoL during follow-up. For some patients, residual OCD symptoms in the years after treatment, even at levels below assumed clinical significance, are associated with compromised QoL. Co-occurring symptoms could be part of the explanation. Assessing QoL after OCD treatment, beyond the clinician-rated symptom severity, could detect patients in need of further treatment and/or assessment. Trial registry: Nordic Long-term Obsessive–Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119.

AB - The present study aimed to investigate the long-term quality of life (QoL) in a large sample of pediatric obsessive–compulsive disorder (OCD) patients. The study included 220 pediatric OCD patients from the Nordic Long-term OCD Treatment Study (NordLOTS) who were evaluated at seven time points before, during, and after stepped-care treatment over a 3-year follow-up period. Data from three symptom severity trajectory classes formed the basis of the QoL evaluation: acute (n = 127, N = 147), slow (n = 46, N = 63), and limited responders (n = 47, N = 59). Patients’ QoL was assessed using parent and child ratings of the revised Questionnaire for Measuring Health-related Quality of Life in Children and Adolescents (KINDL-R). QoL was analyzed by trajectory class using a random mixed effects model. The association between pre-treatment factors and long-term QoL was investigated across classes in a multivariate model. Three years after treatment, the acute responder class had reached QoL levels from a general population, whereas the limited responder class had not. The slow responder class reached norm levels for the child-rated QoL only. Higher levels of co-occurring externalizing symptoms before treatment were associated with lower parent-rated QoL during follow-up, while adolescence and higher levels of co-occurring internalizing symptoms were associated with lower child-rated QoL during follow-up. For some patients, residual OCD symptoms in the years after treatment, even at levels below assumed clinical significance, are associated with compromised QoL. Co-occurring symptoms could be part of the explanation. Assessing QoL after OCD treatment, beyond the clinician-rated symptom severity, could detect patients in need of further treatment and/or assessment. Trial registry: Nordic Long-term Obsessive–Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119.

KW - Children and adolescents

KW - Long-term

KW - Obsessive–compulsive disorder

KW - Quality of life

KW - Stepped-care treatment

KW - Treatment outcome

KW - PSYCHOMETRIC PROPERTIES

KW - FUNCTIONAL IMPAIRMENT

KW - SYMPTOMS

KW - SCHOOL-CHILDREN

KW - MENTAL-HEALTH

KW - TERM OCD TREATMENT

KW - ADOLESCENTS

KW - COGNITIVE-BEHAVIOR THERAPY

KW - GLOBAL ASSESSMENT SCALE

KW - Obsessive-compulsive disorder

KW - QUESTIONNAIRE

UR - http://www.scopus.com/inward/record.url?scp=85104984701&partnerID=8YFLogxK

U2 - 10.1007/s00787-021-01775-w

DO - 10.1007/s00787-021-01775-w

M3 - Journal article

C2 - 33881628

AN - SCOPUS:85104984701

VL - 31

SP - 1377

EP - 1389

JO - European Child & Adolescent Psychiatry

JF - European Child & Adolescent Psychiatry

SN - 1018-8827

IS - 9

ER -