Quality control system response to stochastic growth of amyloid fibrils

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Quality control system response to stochastic growth of amyloid fibrils. / Pigolotti, Simone; Lizana, Ludvig; Otzen, Daniel; Sneppen, Kim.

I: F E B S Letters, Bind 587, Nr. 9, 02.05.2013, s. 1405-1410.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Pigolotti, S, Lizana, L, Otzen, D & Sneppen, K 2013, 'Quality control system response to stochastic growth of amyloid fibrils', F E B S Letters, bind 587, nr. 9, s. 1405-1410. https://doi.org/10.1016/j.febslet.2013.03.018

APA

Pigolotti, S., Lizana, L., Otzen, D., & Sneppen, K. (2013). Quality control system response to stochastic growth of amyloid fibrils. F E B S Letters, 587(9), 1405-1410. https://doi.org/10.1016/j.febslet.2013.03.018

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MLA

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Author

Pigolotti, Simone ; Lizana, Ludvig ; Otzen, Daniel ; Sneppen, Kim. / Quality control system response to stochastic growth of amyloid fibrils. I: F E B S Letters. 2013 ; Bind 587, Nr. 9. s. 1405-1410.

Bibtex

@article{b5fdb5130d33454eb6c1f643a59a0a9e,
title = "Quality control system response to stochastic growth of amyloid fibrils",
abstract = "We introduce a stochastic model describing aggregation of misfolded proteins and degradation by the protein quality control system in a single cell. Aggregate growth is contrasted by the cell quality control system, that attacks them at different stages of the growth process, with an efficiency that decreases with their size. Model parameters are estimated from experimental data. Two qualitatively different behaviors emerge: a homeostatic state, where the quality control system is stable and aggregates of large sizes are not formed, and an oscillatory state, where the quality control system periodically breaks down, allowing for formation of large aggregates. We discuss how these periodic breakdowns may constitute a mechanism for the development of neurodegenerative diseases.",
author = "Simone Pigolotti and Ludvig Lizana and Daniel Otzen and Kim Sneppen",
note = "Copyright {\textcopyright} 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
year = "2013",
month = may,
day = "2",
doi = "10.1016/j.febslet.2013.03.018",
language = "English",
volume = "587",
pages = "1405--1410",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Quality control system response to stochastic growth of amyloid fibrils

AU - Pigolotti, Simone

AU - Lizana, Ludvig

AU - Otzen, Daniel

AU - Sneppen, Kim

N1 - Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PY - 2013/5/2

Y1 - 2013/5/2

N2 - We introduce a stochastic model describing aggregation of misfolded proteins and degradation by the protein quality control system in a single cell. Aggregate growth is contrasted by the cell quality control system, that attacks them at different stages of the growth process, with an efficiency that decreases with their size. Model parameters are estimated from experimental data. Two qualitatively different behaviors emerge: a homeostatic state, where the quality control system is stable and aggregates of large sizes are not formed, and an oscillatory state, where the quality control system periodically breaks down, allowing for formation of large aggregates. We discuss how these periodic breakdowns may constitute a mechanism for the development of neurodegenerative diseases.

AB - We introduce a stochastic model describing aggregation of misfolded proteins and degradation by the protein quality control system in a single cell. Aggregate growth is contrasted by the cell quality control system, that attacks them at different stages of the growth process, with an efficiency that decreases with their size. Model parameters are estimated from experimental data. Two qualitatively different behaviors emerge: a homeostatic state, where the quality control system is stable and aggregates of large sizes are not formed, and an oscillatory state, where the quality control system periodically breaks down, allowing for formation of large aggregates. We discuss how these periodic breakdowns may constitute a mechanism for the development of neurodegenerative diseases.

U2 - 10.1016/j.febslet.2013.03.018

DO - 10.1016/j.febslet.2013.03.018

M3 - Journal article

C2 - 23524241

VL - 587

SP - 1405

EP - 1410

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 9

ER -