Quality control of mRNP in the nucleus

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Quality control of mRNP in the nucleus. / Schmid, Manfred; Jensen, Torben Heick.

I: Chromosoma, Bind 117, Nr. 5, 2008, s. 419-29.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Schmid, Manfred ; Jensen, Torben Heick. / Quality control of mRNP in the nucleus. I: Chromosoma. 2008 ; Bind 117, Nr. 5. s. 419-29.

Bibtex

@article{f518dd6004b611de8317000ea68e967b,
title = "Quality control of mRNP in the nucleus",
abstract = "Formation of functional mRNA-protein particles requires a plethora of nuclear cotranscriptional and posttranscriptional RNA processing and packaging steps. Faithful execution of these events is closely monitored by surveillance systems that prevent nuclear export of, and/or rapidly degrade, faulty transcripts. Parts of this quality control also serve to eliminate a large number of noncoding RNAs produced by RNA polymerase II. Here, we discuss which aberrant features trigger messenger ribonucleoprotein quality control, how the process is executed, and how it is connected to the transcription machinery and the nuclear pore complex.",
keywords = "Cell Nucleus, Humans, Nuclear Pore, RNA Polymerase II, RNA Processing, Post-Transcriptional, RNA Splicing, RNA Stability, RNA, Messenger, Ribonucleoproteins, Transcription, Genetic",
author = "Manfred Schmid and Jensen, {Torben Heick}",
year = "2008",
doi = "10.1007/s00412-008-0166-4",
language = "English",
volume = "117",
pages = "419--29",
journal = "Chromosoma",
issn = "0009-5915",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Quality control of mRNP in the nucleus

AU - Schmid, Manfred

AU - Jensen, Torben Heick

PY - 2008

Y1 - 2008

N2 - Formation of functional mRNA-protein particles requires a plethora of nuclear cotranscriptional and posttranscriptional RNA processing and packaging steps. Faithful execution of these events is closely monitored by surveillance systems that prevent nuclear export of, and/or rapidly degrade, faulty transcripts. Parts of this quality control also serve to eliminate a large number of noncoding RNAs produced by RNA polymerase II. Here, we discuss which aberrant features trigger messenger ribonucleoprotein quality control, how the process is executed, and how it is connected to the transcription machinery and the nuclear pore complex.

AB - Formation of functional mRNA-protein particles requires a plethora of nuclear cotranscriptional and posttranscriptional RNA processing and packaging steps. Faithful execution of these events is closely monitored by surveillance systems that prevent nuclear export of, and/or rapidly degrade, faulty transcripts. Parts of this quality control also serve to eliminate a large number of noncoding RNAs produced by RNA polymerase II. Here, we discuss which aberrant features trigger messenger ribonucleoprotein quality control, how the process is executed, and how it is connected to the transcription machinery and the nuclear pore complex.

KW - Cell Nucleus

KW - Humans

KW - Nuclear Pore

KW - RNA Polymerase II

KW - RNA Processing, Post-Transcriptional

KW - RNA Splicing

KW - RNA Stability

KW - RNA, Messenger

KW - Ribonucleoproteins

KW - Transcription, Genetic

U2 - 10.1007/s00412-008-0166-4

DO - 10.1007/s00412-008-0166-4

M3 - Journal article

C2 - 18563427

VL - 117

SP - 419

EP - 429

JO - Chromosoma

JF - Chromosoma

SN - 0009-5915

IS - 5

ER -