QuagmiR: A cloud-based application for isomiR big data analytics

TY - JOUR

T1 - QuagmiR

T2 - A cloud-based application for isomiR big data analytics

AU - Bofill-De Ros, Xavier

AU - Chen, Kevin

AU - Chen, Susanna

AU - Tesic, Nikola

AU - Randjelovic, Dusan

AU - Skundric, Nikola

AU - Nesic, Svetozar

AU - Varjacic, Vojislav

AU - Williams, Elizabeth H.

AU - Malhotra, Raunaq

AU - Jiang, Minjie

AU - Gu, Shuo

N1 - Publisher Copyright: © The Author(s) 2018. Published by Oxford University Press. All rights reserved.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - MicroRNAs (miRNAs) function as master regulators of gene expression. Recent studies demonstrate that miRNA isoforms (isomiRs) play a unique role in cancer development. Here, we present QuagmiR, the first cloud-based tool to analyze isomiRs from next generation sequencing data. Using a novel and flexible searching algorithm designed for the detection and annotation of heterogeneous isomiRs, it permits extensive customization of the query process and reference databases to meet the user 's diverse research needs.

AB - MicroRNAs (miRNAs) function as master regulators of gene expression. Recent studies demonstrate that miRNA isoforms (isomiRs) play a unique role in cancer development. Here, we present QuagmiR, the first cloud-based tool to analyze isomiRs from next generation sequencing data. Using a novel and flexible searching algorithm designed for the detection and annotation of heterogeneous isomiRs, it permits extensive customization of the query process and reference databases to meet the user 's diverse research needs.

UR - http://www.scopus.com/inward/record.url?scp=85058698197&partnerID=8YFLogxK

U2 - 10.1093/bioinformatics/bty843

DO - 10.1093/bioinformatics/bty843

M3 - Journal article

C2 - 30295744

AN - SCOPUS:85058698197

SN - 1367-4803

VL - 35

SP - 1576

EP - 1578

JO - Bioinformatics

JF - Bioinformatics

IS - 9

ER -