Pyridostigmine Impairs Pulmonary Function in Asthmatic Subjects: Reanalysis of Results From an Observational Study

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  • Martin Rune Hassan Hansen, Det Nationale Forskningscenter for Arbejdsmiljø
  • ,
  • Vivi Schlünssen
The cholinesterase inhibitor drug pyridostigmine can be used prophylactically against some chemical warfare agents. In a previous article in Military Medicine, authors reported exacerbations of symptoms among asthmatic volunteers given pyridostigmine, but no change in objective pulmonary function (forced vital capacity = FVC), and the authors suspected that “exacerbation of asthma symptoms could have been due to a placebo effect”. We provide a re-analysis of the original data in a mixed effect model and show that pyridostigmine caused FVC to decrease by 6.8 [2.8, 10.9] percentage-points of predicted among asthmatics, but not in healthy subjects. Caution is warranted before administering pyridostigmine to asthmatics.

Author's note: This abstract is not included in the published paper.
OriginalsprogEngelsk
Artikelnummerusaa055
TidsskriftMilitary Medicine
Vol/bind185
Nummer7-8
Sider (fra-til)e934-e936
ISSN0026-4075
DOI
StatusUdgivet - aug. 2020

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