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P-type ATPases

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  • Michael Broberg Palmgren, Københavns Universitet, Danmark
  • Poul Nissen
P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably simple with only a single catalytic subunit and carry out large domain motions during transport. The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Phylogenetically, P-type ATPases are divided into five subfamilies, P1-P5. These subfamilies differ with respect to transported ligands and the way they are regulated.
TidsskriftAnnual Review of Biophysics
Sider (fra-til)243-66
Antal sider24
StatusUdgivet - 2011

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