Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in: The Danish High Risk and Resilience Study - VIA 7; A population-based cohort study

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  • Ditte Ellersgaard, Capital Region of Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
  • ,
  • Maja Gregersen, Capital Region of Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
  • ,
  • Katrine Soeborg Spang, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Capital Region of Denmark
  • ,
  • Camilla Christiani, Capital Region of Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
  • ,
  • Birgitte Klee Burton, Capital Region of Denmark
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  • Nicoline Hemager, Capital Region of Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
  • ,
  • Anne Søndergaard
  • Aja Greve
  • Ditte Gantriis
  • Jens Richardt Møllegaard Jepsen, Capital Region of Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
  • ,
  • Ole Mors
  • Kerstin Jessica Plessen, Capital Region of Denmark, Lausanne University Hospital
  • ,
  • Anne Amalie Elgaard Thorup, Københavns Universitet, Capital Region of Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
  • ,
  • Merete Nordentoft, Capital Region of Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

We aimed to examine the prevalence of psychotic experiences (PEs) in children with familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and, in exploratory analyses, to examine the possible associations between PEs and mental disorders as well as level of functioning. A cohort of seven-year-old children with FHR-SZ (N = 199), FHR-BP (N = 118) and controls (N = 196) was recruited through Danish nationwide registers. Lifetime PEs were assessed through interviews using the psychosis section of the 'Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version' (K-SADS-PL). Lifetime DSM-IV diagnoses were ascertained through K-SADS-PL and the level of functioning of the children through 'Children's Global Assessment Scale'. Both children with FHR-SZ (OR = 2.9, 95% CI = 1.4-6.2, p = 0.005) and FHR-BP (OR = 2.9, 95% CI = 1.3-6.7, p = 0.011) had an increased risk of having experienced "severe" PEs compared with controls. In the overall cohort PEs were associated with any lifetime mental disorder, Attention-Deficit/Hyperactivity Disorder, anxiety disorders and a lower level of functioning. The findings of a higher proportion of high risk children reporting PEs could represent an early manifestation of later more severe psychopathology or simply an unspecific transitory symptom. Future follow-up studies of this cohort will explore the predictive value of the occurrence of PEs at age seven.

OriginalsprogEngelsk
TidsskriftSchizophrenia Research
Vol/bind228
Sider (fra-til)510-518
Antal sider9
ISSN0920-9964
DOI
StatusUdgivet - feb. 2021

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