Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study

Rogini Balachandran; Henriette Vind Thaysen; Peter Christensen; Eva Rames Nissen; Mia Skytte O’Toole; Sofie Møgelberg Knutzen; Cecilie Dorthea Rask Buskbjerg; Lisa Maria Wu; Nina Tauber; Ali Amidi; Josefine Tingdal Taube Danielsen; Robert Zachariae; Lene Hjerrild Iversen

doi:10.3390/cancers17071127

Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study

Rogini Balachandran^*, Henriette Vind Thaysen, Peter Christensen, Eva Rames Nissen, Mia Skytte O’Toole, Sofie Møgelberg Knutzen, Cecilie Dorthea Rask Buskbjerg, Lisa Maria Wu, Nina Tauber, Ali Amidi, Josefine Tingdal Taube Danielsen, Robert Zachariae, Lene Hjerrild Iversen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Background: Up to 80% of patients experience late effects (LE) one year after surgery for peritoneal metastases (PM) from colorectal cancer (CRC). We tested the feasibility and outcome of a treatment strategy to address LEs. Methods: During January 2021–May 2023, patients who had undergone surgery for CRC-PM in Denmark were screened for biopsychosocial LEs (anxiety, depression, fear of cancer recurrence, insomnia, cognitive impairment, pain, fatigue). Patients scoring according to clinical cut-offs were referred to a Multi-Disciplinary Team conference (MDT). The patients, surgeon(s), nurse(s), and psychologists participated in the MDT, identified key concerns and proposed a personalized intervention. Pre- and post-intervention, patients completed a “Measure Yourself Concerns and Wellbeing” (MYCaW) questionnaire, rating the two most distressing LEs and general wellbeing on a 7-point Likert scale. Results: Of 28 eligible patients, 13 (59 years (mean), 85% women) accepted referral, participated in the MDT, and were offered a personalized intervention. The intervention was completed by 11 patients. Improvement in MYCaW score was observed 1 month postintervention for all three items: (1) the primary LE (p = 0.003, Hedges’s g 1.54), (2) the secondary LE (p < 0.001, Hedges’s g 1.65), and (3) general wellbeing (p = 0.005, Hedges’s g 1.09). This improvement was sustained 6 months postintervention. The 15 non-participants were, in general, older (66 years (mean), men 73%). Conclusions: Screening for LEs and conducting an MDT can provide a personalized intervention plan, which patients are able to complete and may benefit from.

Originalsprog	Engelsk
Artikelnummer	1127
Tidsskrift	Cancers
Vol/bind	17
Nummer	7
ISSN	2072-6694
DOI	https://doi.org/10.3390/cancers17071127
Status	Udgivet - apr. 2025

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10.3390/cancers17071127

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Balachandran, R., Thaysen, H. V., Christensen, P., Nissen, E. R., O’Toole, M. S., Knutzen, S. M., Buskbjerg, C. D. R., Wu, L. M., Tauber, N., Amidi, A., Danielsen, J. T. T., Zachariae, R., & Iversen, L. H. (2025). Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study. Cancers, 17(7), Artikel 1127. https://doi.org/10.3390/cancers17071127

@article{27ebf38bbc544319825da1b853648dbc,

title = "Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study",

abstract = "Background: Up to 80% of patients experience late effects (LE) one year after surgery for peritoneal metastases (PM) from colorectal cancer (CRC). We tested the feasibility and outcome of a treatment strategy to address LEs. Methods: During January 2021–May 2023, patients who had undergone surgery for CRC-PM in Denmark were screened for biopsychosocial LEs (anxiety, depression, fear of cancer recurrence, insomnia, cognitive impairment, pain, fatigue). Patients scoring according to clinical cut-offs were referred to a Multi-Disciplinary Team conference (MDT). The patients, surgeon(s), nurse(s), and psychologists participated in the MDT, identified key concerns and proposed a personalized intervention. Pre- and post-intervention, patients completed a “Measure Yourself Concerns and Wellbeing” (MYCaW) questionnaire, rating the two most distressing LEs and general wellbeing on a 7-point Likert scale. Results: Of 28 eligible patients, 13 (59 years (mean), 85% women) accepted referral, participated in the MDT, and were offered a personalized intervention. The intervention was completed by 11 patients. Improvement in MYCaW score was observed 1 month postintervention for all three items: (1) the primary LE (p = 0.003, Hedges{\textquoteright}s g 1.54), (2) the secondary LE (p < 0.001, Hedges{\textquoteright}s g 1.65), and (3) general wellbeing (p = 0.005, Hedges{\textquoteright}s g 1.09). This improvement was sustained 6 months postintervention. The 15 non-participants were, in general, older (66 years (mean), men 73%). Conclusions: Screening for LEs and conducting an MDT can provide a personalized intervention plan, which patients are able to complete and may benefit from.",

keywords = "biopsychosocial, colorectal cancer, late effects, peritoneal metastases, psychological intervention",

author = "Rogini Balachandran and Thaysen, {Henriette Vind} and Peter Christensen and Nissen, {Eva Rames} and O{\textquoteright}Toole, {Mia Skytte} and Knutzen, {Sofie M{\o}gelberg} and Buskbjerg, {Cecilie Dorthea Rask} and Wu, {Lisa Maria} and Nina Tauber and Ali Amidi and Danielsen, {Josefine Tingdal Taube} and Robert Zachariae and Iversen, {Lene Hjerrild}",

note = "Publisher Copyright: {\textcopyright} 2025 by the authors.",

year = "2025",

month = apr,

doi = "10.3390/cancers17071127",

language = "English",

volume = "17",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

Balachandran, R, Thaysen, HV, Christensen, P , Nissen, ER, O’Toole, MS, Knutzen, SM , Buskbjerg, CDR , Wu, LM , Tauber, N , Amidi, A , Danielsen, JTT , Zachariae, R & Iversen, LH 2025, 'Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study', Cancers, bind 17, nr. 7, 1127. https://doi.org/10.3390/cancers17071127

Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study. / Balachandran, Rogini; Thaysen, Henriette Vind; Christensen, Peter et al.
I: Cancers, Bind 17, Nr. 7, 1127, 04.2025.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study

AU - Balachandran, Rogini

AU - Thaysen, Henriette Vind

AU - Christensen, Peter

AU - Nissen, Eva Rames

AU - O’Toole, Mia Skytte

AU - Knutzen, Sofie Møgelberg

AU - Buskbjerg, Cecilie Dorthea Rask

AU - Wu, Lisa Maria

AU - Tauber, Nina

AU - Amidi, Ali

AU - Danielsen, Josefine Tingdal Taube

AU - Zachariae, Robert

AU - Iversen, Lene Hjerrild

PY - 2025/4

Y1 - 2025/4

N2 - Background: Up to 80% of patients experience late effects (LE) one year after surgery for peritoneal metastases (PM) from colorectal cancer (CRC). We tested the feasibility and outcome of a treatment strategy to address LEs. Methods: During January 2021–May 2023, patients who had undergone surgery for CRC-PM in Denmark were screened for biopsychosocial LEs (anxiety, depression, fear of cancer recurrence, insomnia, cognitive impairment, pain, fatigue). Patients scoring according to clinical cut-offs were referred to a Multi-Disciplinary Team conference (MDT). The patients, surgeon(s), nurse(s), and psychologists participated in the MDT, identified key concerns and proposed a personalized intervention. Pre- and post-intervention, patients completed a “Measure Yourself Concerns and Wellbeing” (MYCaW) questionnaire, rating the two most distressing LEs and general wellbeing on a 7-point Likert scale. Results: Of 28 eligible patients, 13 (59 years (mean), 85% women) accepted referral, participated in the MDT, and were offered a personalized intervention. The intervention was completed by 11 patients. Improvement in MYCaW score was observed 1 month postintervention for all three items: (1) the primary LE (p = 0.003, Hedges’s g 1.54), (2) the secondary LE (p < 0.001, Hedges’s g 1.65), and (3) general wellbeing (p = 0.005, Hedges’s g 1.09). This improvement was sustained 6 months postintervention. The 15 non-participants were, in general, older (66 years (mean), men 73%). Conclusions: Screening for LEs and conducting an MDT can provide a personalized intervention plan, which patients are able to complete and may benefit from.

AB - Background: Up to 80% of patients experience late effects (LE) one year after surgery for peritoneal metastases (PM) from colorectal cancer (CRC). We tested the feasibility and outcome of a treatment strategy to address LEs. Methods: During January 2021–May 2023, patients who had undergone surgery for CRC-PM in Denmark were screened for biopsychosocial LEs (anxiety, depression, fear of cancer recurrence, insomnia, cognitive impairment, pain, fatigue). Patients scoring according to clinical cut-offs were referred to a Multi-Disciplinary Team conference (MDT). The patients, surgeon(s), nurse(s), and psychologists participated in the MDT, identified key concerns and proposed a personalized intervention. Pre- and post-intervention, patients completed a “Measure Yourself Concerns and Wellbeing” (MYCaW) questionnaire, rating the two most distressing LEs and general wellbeing on a 7-point Likert scale. Results: Of 28 eligible patients, 13 (59 years (mean), 85% women) accepted referral, participated in the MDT, and were offered a personalized intervention. The intervention was completed by 11 patients. Improvement in MYCaW score was observed 1 month postintervention for all three items: (1) the primary LE (p = 0.003, Hedges’s g 1.54), (2) the secondary LE (p < 0.001, Hedges’s g 1.65), and (3) general wellbeing (p = 0.005, Hedges’s g 1.09). This improvement was sustained 6 months postintervention. The 15 non-participants were, in general, older (66 years (mean), men 73%). Conclusions: Screening for LEs and conducting an MDT can provide a personalized intervention plan, which patients are able to complete and may benefit from.

KW - biopsychosocial

KW - colorectal cancer

KW - late effects

KW - peritoneal metastases

KW - psychological intervention

UR - http://www.scopus.com/inward/record.url?scp=105002370481&partnerID=8YFLogxK

U2 - 10.3390/cancers17071127

DO - 10.3390/cancers17071127

M3 - Journal article

C2 - 40227665

AN - SCOPUS:105002370481

SN - 2072-6694

VL - 17

JO - Cancers

JF - Cancers

IS - 7

M1 - 1127

ER -

Psychological Intervention for Patients with Biopsychosocial Late Effects Following Surgery for Colorectal Cancer with Peritoneal Metastases—A Feasibility Study

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