Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Ian Max Møller
  • R. Shyama Prasad Rao, Yenepoya University
  • ,
  • Yuexu Jiang, University of Missouri
  • ,
  • Jay J. Thelen, University of Missouri
  • ,
  • Dong Xu, University of Missouri

To function as a metabolic hub, plant mitochondria have to exchange a wide variety of metabolic intermediates as well as inorganic ions with the cytosol. As identified by proteomic profiling or as predicted by MU-LOC, a newly developed bioinformatics tool, Arabidopsis thaliana mitochondria contain 128 or 143 different transporters, respectively. The largest group is the mitochondrial carrier family, which consists of symporters and antiporters catalyzing secondary active transport of organic acids, amino acids, and nucleotides across the inner mitochondrial membrane. An impressive 97% (58 out of 60) of all the known mitochondrial carrier family members in Arabidopsis have been experimentally identified in isolated mitochondria. In addition to many other secondary transporters, Arabidopsis mitochondria contain the ATP synthase transporters, the mitochondria protein translocase complexes (responsible for protein uptake across the outer and inner membrane), ATP-binding cassette (ABC) transporters, and a number of transporters and channels responsible for allowing water and inorganic ions to move across the inner membrane driven by their transmembrane electrochemical gradient. A few mitochondrial transporters are tissue-specific, development-specific, or stress-response specific, but this is a relatively unexplored area in proteomics that merits much more attention.

OriginalsprogEngelsk
Artikelnummer1190
TidsskriftBiomolecules
Vol/bind10
Nummer8
Antal sider13
DOI
StatusUdgivet - 2020

Se relationer på Aarhus Universitet Citationsformater

ID: 195856995