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Protein ultrastructure and the nanoscience of complement activation

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Protein ultrastructure and the nanoscience of complement activation. / Vorup-Jensen, Thomas; Boesen, Thomas.

I: Advanced Drug Delivery Reviews, 12.06.2011.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{b40465f8cfce4b7c828e241bc6a1a0c9,
title = "Protein ultrastructure and the nanoscience of complement activation",
abstract = "The complement system constitutes an important barrier to infection of the human body. Over more than four decades structural properties of the proteins of the complement system have been investigated with X-ray crystallography, electron microscopy, small-angle scattering, and atomic force microscopy. Here, we review the accumulated evidence that the nm-scaled dimensions and conformational changes of these proteins support functions of the complement system with regard to tissue distribution, molecular crowding effects, avidity binding, and conformational regulation of complement activation. In the targeting of complement activation to the surfaces of nanoparticulate material, such as engineered nanoparticles or fragments of the microbial cell wall, these processes play intimately together. This way the complement system is an excellent example where nanoscience may serve to unravel the molecular biology of the immune response.",
author = "Thomas Vorup-Jensen and Thomas Boesen",
note = "Copyright {\textcopyright} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
month = jun,
day = "12",
doi = "10.1016/j.addr.2011.05.023",
language = "English",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Protein ultrastructure and the nanoscience of complement activation

AU - Vorup-Jensen, Thomas

AU - Boesen, Thomas

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/6/12

Y1 - 2011/6/12

N2 - The complement system constitutes an important barrier to infection of the human body. Over more than four decades structural properties of the proteins of the complement system have been investigated with X-ray crystallography, electron microscopy, small-angle scattering, and atomic force microscopy. Here, we review the accumulated evidence that the nm-scaled dimensions and conformational changes of these proteins support functions of the complement system with regard to tissue distribution, molecular crowding effects, avidity binding, and conformational regulation of complement activation. In the targeting of complement activation to the surfaces of nanoparticulate material, such as engineered nanoparticles or fragments of the microbial cell wall, these processes play intimately together. This way the complement system is an excellent example where nanoscience may serve to unravel the molecular biology of the immune response.

AB - The complement system constitutes an important barrier to infection of the human body. Over more than four decades structural properties of the proteins of the complement system have been investigated with X-ray crystallography, electron microscopy, small-angle scattering, and atomic force microscopy. Here, we review the accumulated evidence that the nm-scaled dimensions and conformational changes of these proteins support functions of the complement system with regard to tissue distribution, molecular crowding effects, avidity binding, and conformational regulation of complement activation. In the targeting of complement activation to the surfaces of nanoparticulate material, such as engineered nanoparticles or fragments of the microbial cell wall, these processes play intimately together. This way the complement system is an excellent example where nanoscience may serve to unravel the molecular biology of the immune response.

U2 - 10.1016/j.addr.2011.05.023

DO - 10.1016/j.addr.2011.05.023

M3 - Journal article

C2 - 21699938

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

ER -