Proteasomal oscillation during mild heat shock in aging human skin fibroblasts

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Proteasomal oscillation during mild heat shock in aging human skin fibroblasts. / Kraft, David Christian; Deocaris, Custer C; Rattan, Suresh I S.

I: New York Academy of Sciences. Annals, Bind 1067, 2006, s. 224-7.

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Kraft, David Christian ; Deocaris, Custer C ; Rattan, Suresh I S. / Proteasomal oscillation during mild heat shock in aging human skin fibroblasts. I: New York Academy of Sciences. Annals. 2006 ; Bind 1067. s. 224-7.

Bibtex

@article{b550c120b28011dea554000ea68e967b,
title = "Proteasomal oscillation during mild heat shock in aging human skin fibroblasts",
abstract = "Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.",
keywords = "Adult, Cell Aging, Cells, Cultured, Female, Fibroblasts, Heat-Shock Response, Humans, Proteasome Endopeptidase Complex, Skin Aging, Time Factors",
author = "Kraft, {David Christian} and Deocaris, {Custer C} and Rattan, {Suresh I S}",
year = "2006",
doi = "10.1196/annals.1354.028",
language = "English",
volume = "1067",
pages = "224--7",
journal = "New York Academy of Sciences. Annals",
issn = "0077-8923",
publisher = "Wiley-Blackwell Publishing, Inc",

}

RIS

TY - JOUR

T1 - Proteasomal oscillation during mild heat shock in aging human skin fibroblasts

AU - Kraft, David Christian

AU - Deocaris, Custer C

AU - Rattan, Suresh I S

PY - 2006

Y1 - 2006

N2 - Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.

AB - Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.

KW - Adult

KW - Cell Aging

KW - Cells, Cultured

KW - Female

KW - Fibroblasts

KW - Heat-Shock Response

KW - Humans

KW - Proteasome Endopeptidase Complex

KW - Skin Aging

KW - Time Factors

U2 - 10.1196/annals.1354.028

DO - 10.1196/annals.1354.028

M3 - Journal article

C2 - 16803990

VL - 1067

SP - 224

EP - 227

JO - New York Academy of Sciences. Annals

JF - New York Academy of Sciences. Annals

SN - 0077-8923

ER -