Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers

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Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers. / Choi, Karmel W; Chen, Chia-Yen; Ursano, Robert J; Sun, Xiaoying; Jain, Sonia; Kessler, Ronald C; Koenen, Karestan C; Wang, Min-Jung; Wynn, Gary H; Campbell-Sills, Laura; Stein, Murray B; Smoller, Jordan W; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

I: Psychological Medicine, Bind 50, Nr. 5, 04.2020, s. 737-745.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Choi, KW, Chen, C-Y, Ursano, RJ, Sun, X, Jain, S, Kessler, RC, Koenen, KC, Wang, M-J, Wynn, GH, Campbell-Sills, L, Stein, MB, Smoller, JW & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2020, 'Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers', Psychological Medicine, bind 50, nr. 5, s. 737-745. https://doi.org/10.1017/S0033291719000527

APA

Choi, K. W., Chen, C-Y., Ursano, R. J., Sun, X., Jain, S., Kessler, R. C., Koenen, K. C., Wang, M-J., Wynn, G. H., Campbell-Sills, L., Stein, M. B., Smoller, J. W., & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2020). Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers. Psychological Medicine, 50(5), 737-745. https://doi.org/10.1017/S0033291719000527

CBE

Choi KW, Chen C-Y, Ursano RJ, Sun X, Jain S, Kessler RC, Koenen KC, Wang M-J, Wynn GH, Campbell-Sills L, Stein MB, Smoller JW, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. 2020. Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers. Psychological Medicine. 50(5):737-745. https://doi.org/10.1017/S0033291719000527

MLA

Vancouver

Author

Choi, Karmel W ; Chen, Chia-Yen ; Ursano, Robert J ; Sun, Xiaoying ; Jain, Sonia ; Kessler, Ronald C ; Koenen, Karestan C ; Wang, Min-Jung ; Wynn, Gary H ; Campbell-Sills, Laura ; Stein, Murray B ; Smoller, Jordan W ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. / Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers. I: Psychological Medicine. 2020 ; Bind 50, Nr. 5. s. 737-745.

Bibtex

@article{979c75001c9a4228bb18bb6cf63152f2,
title = "Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers",
abstract = "BACKGROUND: Whereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.METHODS: Data were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at pre-deployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from a large-scale genome-wide association study of major depression. We first examined the main effects of the MDD PRS and each protective factor on incident MDD. We then tested the effects of each protective factor on incident MDD across strata of polygenic risk.RESULTS: Polygenic risk showed a dose-response relationship to depression, such that soldiers at high polygenic risk had greatest odds for incident MDD. Both unit cohesion and trait resilience were prospectively associated with reduced risk for incident MDD. Notably, the protective effect of unit cohesion persisted even in soldiers at highest polygenic risk.CONCLUSIONS: Polygenic risk was associated with new-onset MDD in deployed soldiers. However, unit cohesion - an index of perceived support and morale - was protective against incident MDD even among those at highest genetic risk, and may represent a potent target for promoting resilience in vulnerable soldiers. Findings illustrate the value of combining genomic and environmental data in a prospective design to identify robust protective factors for mental health.",
keywords = "Depression, genetics, longitudinal, polygenic risk, resilience, social support",
author = "Choi, {Karmel W} and Chia-Yen Chen and Ursano, {Robert J} and Xiaoying Sun and Sonia Jain and Kessler, {Ronald C} and Koenen, {Karestan C} and Min-Jung Wang and Wynn, {Gary H} and Laura Campbell-Sills and Stein, {Murray B} and Smoller, {Jordan W} and {Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium} and Jakob Grove",
year = "2020",
month = apr,
doi = "10.1017/S0033291719000527",
language = "English",
volume = "50",
pages = "737--745",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers

AU - Choi, Karmel W

AU - Chen, Chia-Yen

AU - Ursano, Robert J

AU - Sun, Xiaoying

AU - Jain, Sonia

AU - Kessler, Ronald C

AU - Koenen, Karestan C

AU - Wang, Min-Jung

AU - Wynn, Gary H

AU - Campbell-Sills, Laura

AU - Stein, Murray B

AU - Smoller, Jordan W

AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

AU - Grove, Jakob

PY - 2020/4

Y1 - 2020/4

N2 - BACKGROUND: Whereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.METHODS: Data were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at pre-deployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from a large-scale genome-wide association study of major depression. We first examined the main effects of the MDD PRS and each protective factor on incident MDD. We then tested the effects of each protective factor on incident MDD across strata of polygenic risk.RESULTS: Polygenic risk showed a dose-response relationship to depression, such that soldiers at high polygenic risk had greatest odds for incident MDD. Both unit cohesion and trait resilience were prospectively associated with reduced risk for incident MDD. Notably, the protective effect of unit cohesion persisted even in soldiers at highest polygenic risk.CONCLUSIONS: Polygenic risk was associated with new-onset MDD in deployed soldiers. However, unit cohesion - an index of perceived support and morale - was protective against incident MDD even among those at highest genetic risk, and may represent a potent target for promoting resilience in vulnerable soldiers. Findings illustrate the value of combining genomic and environmental data in a prospective design to identify robust protective factors for mental health.

AB - BACKGROUND: Whereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.METHODS: Data were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at pre-deployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from a large-scale genome-wide association study of major depression. We first examined the main effects of the MDD PRS and each protective factor on incident MDD. We then tested the effects of each protective factor on incident MDD across strata of polygenic risk.RESULTS: Polygenic risk showed a dose-response relationship to depression, such that soldiers at high polygenic risk had greatest odds for incident MDD. Both unit cohesion and trait resilience were prospectively associated with reduced risk for incident MDD. Notably, the protective effect of unit cohesion persisted even in soldiers at highest polygenic risk.CONCLUSIONS: Polygenic risk was associated with new-onset MDD in deployed soldiers. However, unit cohesion - an index of perceived support and morale - was protective against incident MDD even among those at highest genetic risk, and may represent a potent target for promoting resilience in vulnerable soldiers. Findings illustrate the value of combining genomic and environmental data in a prospective design to identify robust protective factors for mental health.

KW - Depression

KW - genetics

KW - longitudinal

KW - polygenic risk

KW - resilience

KW - social support

U2 - 10.1017/S0033291719000527

DO - 10.1017/S0033291719000527

M3 - Journal article

C2 - 30982473

VL - 50

SP - 737

EP - 745

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 5

ER -