Prognostic scoring models in parotid gland carcinoma

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DOI

  • Marie Westergaard-Nielsen, Department of Otorhinolaryngology, Odense Universitetshospital
  • ,
  • Sören Möller, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  • ,
  • Christian Godballe, Department of Otorhinolaryngology, Odense Universitetshospital
  • ,
  • Jesper Grau Eriksen
  • Stine Rosenkilde Larsen, Department of Pathology, Odense University Hospital, Odense
  • ,
  • Katalin Kiss, Department of Pathology, Rigshospitalet, Copenhagen
  • ,
  • Tina Agander, Department of Pathology, Rigshospitalet, Copenhagen
  • ,
  • Benedicte Parm Ulhøi
  • ,
  • Birgitte Charabi, Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital.
  • ,
  • Tejs Ehlers Klug
  • Henrik Jacobsen, Aalborg Universitet
  • ,
  • Jørgen Johansen, Department of Oncology, Odense University Hospital, Odense
  • ,
  • Claus Andrup Kristensen, Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
  • ,
  • Elo Andersen, Department of Oncology, Herlev Hospital, Herlev
  • ,
  • Maria Andersen, Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.
  • ,
  • Kristine Bjørndal, Department of Otorhinolaryngology - Head & Neck Surgery, Odense University Hospital, Denmark.

BACKGROUND: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.

METHODS: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.

RESULTS: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.

CONCLUSION: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.

OriginalsprogEngelsk
TidsskriftHead & Neck (Print Edition)
Vol/bind43
Nummer7
Sider (fra-til)2081-2090
Antal sider10
ISSN1043-3074
DOI
StatusUdgivet - jul. 2021

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