Prognostic scoring models in parotid gland carcinoma

Marie Westergaard-Nielsen; Sören Möller; Christian Godballe; Jesper Grau Eriksen; Stine Rosenkilde Larsen; Katalin Kiss; Tina Agander; Benedicte Parm Ulhøi; Birgitte Charabi; Tejs Ehlers Klug; Henrik Jacobsen; Jørgen Johansen; Claus Andrup Kristensen; Elo Andersen; Maria Andersen; Kristine Bjørndal

doi:10.1002/hed.26672

Prognostic scoring models in parotid gland carcinoma

Marie Westergaard-Nielsen^*, Sören Möller, Christian Godballe, Jesper Grau Eriksen, Stine Rosenkilde Larsen, Katalin Kiss, Tina Agander, Benedicte Parm Ulhøi, Birgitte Charabi, Tejs Ehlers Klug, Henrik Jacobsen, Jørgen Johansen, Claus Andrup Kristensen, Elo Andersen, Maria Andersen, Kristine Bjørndal

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

BACKGROUND: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.

METHODS: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.

RESULTS: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.

CONCLUSION: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.

Originalsprog	Engelsk
Tidsskrift	Head & Neck (Print Edition)
Vol/bind	43
Nummer	7
Sider (fra-til)	2081-2090
Antal sider	10
ISSN	1043-3074
DOI	https://doi.org/10.1002/hed.26672
Status	Udgivet - jul. 2021

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10.1002/hed.26672

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Westergaard-Nielsen, M., Möller, S., Godballe, C., Eriksen, J. G., Larsen, S. R., Kiss, K., Agander, T., Parm Ulhøi, B., Charabi, B., Ehlers Klug, T., Jacobsen, H., Johansen, J., Kristensen, C. A., Andersen, E., Andersen, M., & Bjørndal, K. (2021). Prognostic scoring models in parotid gland carcinoma. Head & Neck (Print Edition), 43(7), 2081-2090. https://doi.org/10.1002/hed.26672

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title = "Prognostic scoring models in parotid gland carcinoma",

abstract = "BACKGROUND: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.METHODS: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.RESULTS: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.CONCLUSION: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.",

keywords = "follow-up, parotid gland carcinoma, prognosis, prognostic scoring model, recurrence risk",

author = "Marie Westergaard-Nielsen and S{\"o}ren M{\"o}ller and Christian Godballe and Eriksen, {Jesper Grau} and Larsen, {Stine Rosenkilde} and Katalin Kiss and Tina Agander and {Parm Ulh{\o}i}, Benedicte and Birgitte Charabi and {Ehlers Klug}, Tejs and Henrik Jacobsen and J{\o}rgen Johansen and Kristensen, {Claus Andrup} and Elo Andersen and Maria Andersen and Kristine Bj{\o}rndal",

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year = "2021",

month = jul,

doi = "10.1002/hed.26672",

language = "English",

volume = "43",

pages = "2081--2090",

journal = "Head & Neck (Print Edition)",

issn = "1043-3074",

publisher = "JohnWiley & Sons, Inc.",

number = "7",

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Westergaard-Nielsen, M, Möller, S, Godballe, C, Eriksen, JG, Larsen, SR, Kiss, K, Agander, T, Parm Ulhøi, B, Charabi, B, Ehlers Klug, T, Jacobsen, H, Johansen, J, Kristensen, CA, Andersen, E, Andersen, M & Bjørndal, K 2021, 'Prognostic scoring models in parotid gland carcinoma', Head & Neck (Print Edition), bind 43, nr. 7, s. 2081-2090. https://doi.org/10.1002/hed.26672

TY - JOUR

T1 - Prognostic scoring models in parotid gland carcinoma

AU - Westergaard-Nielsen, Marie

AU - Möller, Sören

AU - Godballe, Christian

AU - Eriksen, Jesper Grau

AU - Larsen, Stine Rosenkilde

AU - Kiss, Katalin

AU - Agander, Tina

AU - Parm Ulhøi, Benedicte

AU - Charabi, Birgitte

AU - Ehlers Klug, Tejs

AU - Jacobsen, Henrik

AU - Johansen, Jørgen

AU - Kristensen, Claus Andrup

AU - Andersen, Elo

AU - Andersen, Maria

AU - Bjørndal, Kristine

PY - 2021/7

Y1 - 2021/7

N2 - BACKGROUND: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.METHODS: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.RESULTS: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.CONCLUSION: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.

AB - BACKGROUND: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.METHODS: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.RESULTS: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.CONCLUSION: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.

KW - follow-up

KW - parotid gland carcinoma

KW - prognosis

KW - prognostic scoring model

KW - recurrence risk

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U2 - 10.1002/hed.26672

DO - 10.1002/hed.26672

M3 - Journal article

C2 - 33734517

SN - 1043-3074

VL - 43

SP - 2081

EP - 2090

JO - Head & Neck (Print Edition)

JF - Head & Neck (Print Edition)

IS - 7

ER -

Prognostic scoring models in parotid gland carcinoma

Abstract

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