Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Prevalence of infective endocarditis in patients with positive blood cultures : a Danish nationwide study. / Østergaard, Lauge; Bruun, Niels Eske; Voldstedlund, Marianne; Arpi, Magnus; Andersen, Christian Østergaard; Schønheyder, Henrik C; Lemming, Lars; Rosenvinge, Flemming; Valeur, Nana; Søgaard, Peter; Andersen, Paal Skytt; Skov, Robert; Chen, Ming; Iversen, Kasper; Gill, Sabine; Lauridsen, Trine Kiilerich; Dahl, Anders; Østergaard, Louise Bruun; Povlsen, Jonas Agerlund; Moser, Claus; Bundgaard, Henning; Køber, Lars; Fosbøl, Emil Loldrup.

I: European Heart Journal, Bind 40, Nr. 39, 10.2019, s. 3237-3244.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Østergaard, L, Bruun, NE, Voldstedlund, M, Arpi, M, Andersen, CØ, Schønheyder, HC, Lemming, L, Rosenvinge, F, Valeur, N, Søgaard, P, Andersen, PS, Skov, R, Chen, M, Iversen, K, Gill, S, Lauridsen, TK, Dahl, A, Østergaard, LB, Povlsen, JA, Moser, C, Bundgaard, H, Køber, L & Fosbøl, EL 2019, 'Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study', European Heart Journal, bind 40, nr. 39, s. 3237-3244. https://doi.org/10.1093/eurheartj/ehz327

APA

Østergaard, L., Bruun, N. E., Voldstedlund, M., Arpi, M., Andersen, C. Ø., Schønheyder, H. C., Lemming, L., Rosenvinge, F., Valeur, N., Søgaard, P., Andersen, P. S., Skov, R., Chen, M., Iversen, K., Gill, S., Lauridsen, T. K., Dahl, A., Østergaard, L. B., Povlsen, J. A., ... Fosbøl, E. L. (2019). Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study. European Heart Journal, 40(39), 3237-3244. https://doi.org/10.1093/eurheartj/ehz327

CBE

Østergaard L, Bruun NE, Voldstedlund M, Arpi M, Andersen CØ, Schønheyder HC, Lemming L, Rosenvinge F, Valeur N, Søgaard P, Andersen PS, Skov R, Chen M, Iversen K, Gill S, Lauridsen TK, Dahl A, Østergaard LB, Povlsen JA, Moser C, Bundgaard H, Køber L, Fosbøl EL. 2019. Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study. European Heart Journal. 40(39):3237-3244. https://doi.org/10.1093/eurheartj/ehz327

MLA

Vancouver

Østergaard L, Bruun NE, Voldstedlund M, Arpi M, Andersen CØ, Schønheyder HC o.a. Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study. European Heart Journal. 2019 okt;40(39):3237-3244. https://doi.org/10.1093/eurheartj/ehz327

Author

Østergaard, Lauge ; Bruun, Niels Eske ; Voldstedlund, Marianne ; Arpi, Magnus ; Andersen, Christian Østergaard ; Schønheyder, Henrik C ; Lemming, Lars ; Rosenvinge, Flemming ; Valeur, Nana ; Søgaard, Peter ; Andersen, Paal Skytt ; Skov, Robert ; Chen, Ming ; Iversen, Kasper ; Gill, Sabine ; Lauridsen, Trine Kiilerich ; Dahl, Anders ; Østergaard, Louise Bruun ; Povlsen, Jonas Agerlund ; Moser, Claus ; Bundgaard, Henning ; Køber, Lars ; Fosbøl, Emil Loldrup. / Prevalence of infective endocarditis in patients with positive blood cultures : a Danish nationwide study. I: European Heart Journal. 2019 ; Bind 40, Nr. 39. s. 3237-3244.

Bibtex

@article{c786a5d1d05f488fa40623bcdcf3d67a,
title = "Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study",
abstract = "AIMS: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE.METHODS AND RESULTS: By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010-2011, 2012-2013, 2014-2015, and 2016-2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age.CONCLUSION: For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI.",
author = "Lauge {\O}stergaard and Bruun, {Niels Eske} and Marianne Voldstedlund and Magnus Arpi and Andersen, {Christian {\O}stergaard} and Sch{\o}nheyder, {Henrik C} and Lars Lemming and Flemming Rosenvinge and Nana Valeur and Peter S{\o}gaard and Andersen, {Paal Skytt} and Robert Skov and Ming Chen and Kasper Iversen and Sabine Gill and Lauridsen, {Trine Kiilerich} and Anders Dahl and {\O}stergaard, {Louise Bruun} and Povlsen, {Jonas Agerlund} and Claus Moser and Henning Bundgaard and Lars K{\o}ber and Fosb{\o}l, {Emil Loldrup}",
note = "Published on behalf of the European Society of Cardiology. All rights reserved. {\textcopyright} The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.",
year = "2019",
month = oct,
doi = "10.1093/eurheartj/ehz327",
language = "English",
volume = "40",
pages = "3237--3244",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "39",

}

RIS

TY - JOUR

T1 - Prevalence of infective endocarditis in patients with positive blood cultures

T2 - a Danish nationwide study

AU - Østergaard, Lauge

AU - Bruun, Niels Eske

AU - Voldstedlund, Marianne

AU - Arpi, Magnus

AU - Andersen, Christian Østergaard

AU - Schønheyder, Henrik C

AU - Lemming, Lars

AU - Rosenvinge, Flemming

AU - Valeur, Nana

AU - Søgaard, Peter

AU - Andersen, Paal Skytt

AU - Skov, Robert

AU - Chen, Ming

AU - Iversen, Kasper

AU - Gill, Sabine

AU - Lauridsen, Trine Kiilerich

AU - Dahl, Anders

AU - Østergaard, Louise Bruun

AU - Povlsen, Jonas Agerlund

AU - Moser, Claus

AU - Bundgaard, Henning

AU - Køber, Lars

AU - Fosbøl, Emil Loldrup

N1 - Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.

PY - 2019/10

Y1 - 2019/10

N2 - AIMS: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE.METHODS AND RESULTS: By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010-2011, 2012-2013, 2014-2015, and 2016-2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age.CONCLUSION: For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI.

AB - AIMS: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE.METHODS AND RESULTS: By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010-2011, 2012-2013, 2014-2015, and 2016-2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age.CONCLUSION: For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI.

U2 - 10.1093/eurheartj/ehz327

DO - 10.1093/eurheartj/ehz327

M3 - Journal article

C2 - 31145782

VL - 40

SP - 3237

EP - 3244

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 39

ER -