Prevalence of cervical, oral, and anal human papillomavirus infection in women living with HIV in Denmark - The SHADE cohort study

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  • Kristina Thorsteinsson, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark. Electronic address: Kristina.thorsteinsson@regionh.dk.
  • ,
  • Merete Storgaard
  • Terese L Katzenstein, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark; Institute of Clinical Medicine, University of Copenhagen, Denmark.
  • ,
  • Steen Ladelund, Københavns Universitet
  • ,
  • Frederikke F Rönsholt, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • ,
  • Isik Somuncu Johansen, a Department of Infectious Diseases , Odense University Hospital , Odense , Denmark.
  • ,
  • Gitte Pedersen
  • Anne Gaardsting, Københavns Universitet
  • ,
  • Lars Nørregård Nielsen, Department of Infectious Diseases, Nordsjællands Hospital, Copenhagen University Hospital, Denmark.
  • ,
  • Jesper Bonde, Molecular Pathology Laboratory, Department of Pathology, Hvidovre, Copenhagen University Hospital, Copenhagen, Denmark.
  • ,
  • Anne-Mette Lebech, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

BACKGROUND: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers.

OBJECTIVES: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark.

STUDY DESIGN: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection. Logistic regression models were used to identify predictors of anal and oral HPV.

RESULTS: A total of 214 of 334 WLWH had sufficient DNA for analysis at all three anatomical sites and were included in analyses. Cervical, oral, and anal high-risk (hr) HPV prevalence were 28.0%, 3.7% and 39.3%. Most frequent i) cervical, ii) oral and iii) anal hrHPV genotypes were i) hrHPV58 (8.4%), 52 (5.1%), 16 (5.1%) and 51 (5.1%); ii) 52 (1.4%) and iii) 51 (9.3%), 58 (8.9%), 16 (7.0%) and 18 (7.0%). Among present cervical, oral, and anal hrHPV genotypes, 6.7%, 12.5% and 17.9% were targeted by the 2-or 4-valent HPV vaccines, whereas 50.0%, 50.0% and 42.9% of hrHPV genotypes were covered by the 9-valent HPV vaccine. Anal HPV infection was predicted by cervical HPV infection (adjusted OR 4.47 (95%CI 2.25-8.89)).

CONCLUSION: Cervical and anal HPV infection were highly prevalent in WLWH. Non-16/18 hrHPV genotypes were predominant at all anatomical sites. Almost half of all hrHPV infections at the three anatomical sites could have been prevented by childhood/adolescent vaccination with the 9-valent HPV vaccine.

OriginalsprogEngelsk
TidsskriftJournal of Clinical Virology
Vol/bind105
Sider (fra-til)64-71
Antal sider8
ISSN1386-6532
DOI
StatusUdgivet - aug. 2018

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