Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients: results from the DANISH trial

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Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients : results from the DANISH trial. / Boas, Rune; Thune, Jens Jakob; Pehrson, Steen; Køber, Lars; Nielsen, Jens C; Videbæk, Lars; Haarbo, Jens; Korup, Eva; Bruun, Niels Eske; Brandes, Axel; Eiskjær, Hans; Thøgersen, Anna M; Philbert, Berit T; Svendsen, Jesper Hastrup; Dixen, Ulrik.

I: Europace, Bind 23, Nr. 4, 04.2021, s. 587–595.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Boas, R, Thune, JJ, Pehrson, S, Køber, L, Nielsen, JC, Videbæk, L, Haarbo, J, Korup, E, Bruun, NE, Brandes, A, Eiskjær, H, Thøgersen, AM, Philbert, BT, Svendsen, JH & Dixen, U 2021, 'Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients: results from the DANISH trial', Europace, bind 23, nr. 4, s. 587–595. https://doi.org/10.1093/europace/euaa341

APA

Boas, R., Thune, J. J., Pehrson, S., Køber, L., Nielsen, J. C., Videbæk, L., Haarbo, J., Korup, E., Bruun, N. E., Brandes, A., Eiskjær, H., Thøgersen, A. M., Philbert, B. T., Svendsen, J. H., & Dixen, U. (2021). Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients: results from the DANISH trial. Europace, 23(4), 587–595. https://doi.org/10.1093/europace/euaa341

CBE

Boas R, Thune JJ, Pehrson S, Køber L, Nielsen JC, Videbæk L, Haarbo J, Korup E, Bruun NE, Brandes A, Eiskjær H, Thøgersen AM, Philbert BT, Svendsen JH, Dixen U. 2021. Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients: results from the DANISH trial. Europace. 23(4):587–595. https://doi.org/10.1093/europace/euaa341

MLA

Vancouver

Author

Boas, Rune ; Thune, Jens Jakob ; Pehrson, Steen ; Køber, Lars ; Nielsen, Jens C ; Videbæk, Lars ; Haarbo, Jens ; Korup, Eva ; Bruun, Niels Eske ; Brandes, Axel ; Eiskjær, Hans ; Thøgersen, Anna M ; Philbert, Berit T ; Svendsen, Jesper Hastrup ; Dixen, Ulrik. / Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients : results from the DANISH trial. I: Europace. 2021 ; Bind 23, Nr. 4. s. 587–595.

Bibtex

@article{ef5a24a73fab4f0c84e7a06dda878ce7,
title = "Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients: results from the DANISH trial",
abstract = "AIMS: Improved risk stratification to identify non-ischaemic heart failure patients who will benefit from primary prophylactic implantable cardioverter-defibrillator (ICD) is needed. We examined the potential of ventricular arrhythmia to identify patients who could benefit from an ICD.METHODS AND RESULTS: A total of 850 non-ischaemic systolic heart failure patients with left ventricle ≤35% and elevated N-terminal pro-brain natriuretic peptides had a 24-h Holter monitor recording performed. We examined present non-sustained ventricular tachycardia (NSVT), defined as ≥3 consecutive premature ventricular contractions (PVCs) with a rate of ≥100/min, and number of PVCs per hour stratified into low (<30) and high burden (≥30) groups. Outcome measures were overall mortality, sudden cardiac death (SCD), and cardiovascular death (CVD). In total, 193 patients died, 49 from SCD and 125 from CVD. Non-sustained ventricular tachycardia (365 patients) was significantly associated with increased all-cause mortality [hazard ratio (HR) 1.47; 95% confidence interval (CI) 1.07-2.03; P = 0.02] and to CVD (HR 1.89; CI 1.25-2.87; P = 0.003). High burden PVC (352 patients) was associated with increased all-cause mortality (HR1.38; CI 1.00-1.90; P = 0.046) and with CVD (HR 1.78; CI 1.19-2.66; P = 0.005). There was no statistically significant association with SCD for neither NSVT nor PVC. In interaction analyses, neither NSVT (P = 0.56) nor high burden of PVC (P = 0.97) was associated with survival benefit from ICD implantation.CONCLUSION: Ventricular arrhythmia in non-ischaemic heart failure patients was associated with a worse prognosis but could not be used to stratify patients to ICD implantation.",
author = "Rune Boas and Thune, {Jens Jakob} and Steen Pehrson and Lars K{\o}ber and Nielsen, {Jens C} and Lars Videb{\ae}k and Jens Haarbo and Eva Korup and Bruun, {Niels Eske} and Axel Brandes and Hans Eiskj{\ae}r and Th{\o}gersen, {Anna M} and Philbert, {Berit T} and Svendsen, {Jesper Hastrup} and Ulrik Dixen",
note = "Published on behalf of the European Society of Cardiology. All rights reserved. {\textcopyright} The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.",
year = "2021",
month = apr,
doi = "10.1093/europace/euaa341",
language = "English",
volume = "23",
pages = "587–595",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Prevalence and prognostic association of ventricular arrhythmia in non-ischaemic heart failure patients

T2 - results from the DANISH trial

AU - Boas, Rune

AU - Thune, Jens Jakob

AU - Pehrson, Steen

AU - Køber, Lars

AU - Nielsen, Jens C

AU - Videbæk, Lars

AU - Haarbo, Jens

AU - Korup, Eva

AU - Bruun, Niels Eske

AU - Brandes, Axel

AU - Eiskjær, Hans

AU - Thøgersen, Anna M

AU - Philbert, Berit T

AU - Svendsen, Jesper Hastrup

AU - Dixen, Ulrik

N1 - Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.

PY - 2021/4

Y1 - 2021/4

N2 - AIMS: Improved risk stratification to identify non-ischaemic heart failure patients who will benefit from primary prophylactic implantable cardioverter-defibrillator (ICD) is needed. We examined the potential of ventricular arrhythmia to identify patients who could benefit from an ICD.METHODS AND RESULTS: A total of 850 non-ischaemic systolic heart failure patients with left ventricle ≤35% and elevated N-terminal pro-brain natriuretic peptides had a 24-h Holter monitor recording performed. We examined present non-sustained ventricular tachycardia (NSVT), defined as ≥3 consecutive premature ventricular contractions (PVCs) with a rate of ≥100/min, and number of PVCs per hour stratified into low (<30) and high burden (≥30) groups. Outcome measures were overall mortality, sudden cardiac death (SCD), and cardiovascular death (CVD). In total, 193 patients died, 49 from SCD and 125 from CVD. Non-sustained ventricular tachycardia (365 patients) was significantly associated with increased all-cause mortality [hazard ratio (HR) 1.47; 95% confidence interval (CI) 1.07-2.03; P = 0.02] and to CVD (HR 1.89; CI 1.25-2.87; P = 0.003). High burden PVC (352 patients) was associated with increased all-cause mortality (HR1.38; CI 1.00-1.90; P = 0.046) and with CVD (HR 1.78; CI 1.19-2.66; P = 0.005). There was no statistically significant association with SCD for neither NSVT nor PVC. In interaction analyses, neither NSVT (P = 0.56) nor high burden of PVC (P = 0.97) was associated with survival benefit from ICD implantation.CONCLUSION: Ventricular arrhythmia in non-ischaemic heart failure patients was associated with a worse prognosis but could not be used to stratify patients to ICD implantation.

AB - AIMS: Improved risk stratification to identify non-ischaemic heart failure patients who will benefit from primary prophylactic implantable cardioverter-defibrillator (ICD) is needed. We examined the potential of ventricular arrhythmia to identify patients who could benefit from an ICD.METHODS AND RESULTS: A total of 850 non-ischaemic systolic heart failure patients with left ventricle ≤35% and elevated N-terminal pro-brain natriuretic peptides had a 24-h Holter monitor recording performed. We examined present non-sustained ventricular tachycardia (NSVT), defined as ≥3 consecutive premature ventricular contractions (PVCs) with a rate of ≥100/min, and number of PVCs per hour stratified into low (<30) and high burden (≥30) groups. Outcome measures were overall mortality, sudden cardiac death (SCD), and cardiovascular death (CVD). In total, 193 patients died, 49 from SCD and 125 from CVD. Non-sustained ventricular tachycardia (365 patients) was significantly associated with increased all-cause mortality [hazard ratio (HR) 1.47; 95% confidence interval (CI) 1.07-2.03; P = 0.02] and to CVD (HR 1.89; CI 1.25-2.87; P = 0.003). High burden PVC (352 patients) was associated with increased all-cause mortality (HR1.38; CI 1.00-1.90; P = 0.046) and with CVD (HR 1.78; CI 1.19-2.66; P = 0.005). There was no statistically significant association with SCD for neither NSVT nor PVC. In interaction analyses, neither NSVT (P = 0.56) nor high burden of PVC (P = 0.97) was associated with survival benefit from ICD implantation.CONCLUSION: Ventricular arrhythmia in non-ischaemic heart failure patients was associated with a worse prognosis but could not be used to stratify patients to ICD implantation.

U2 - 10.1093/europace/euaa341

DO - 10.1093/europace/euaa341

M3 - Journal article

C2 - 33257933

VL - 23

SP - 587

EP - 595

JO - Europace

JF - Europace

SN - 1099-5129

IS - 4

ER -