Pregnancy outcome in four women with inflammatory bowel disease treated with budesonide MMX

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ABSTRACT
Background: Maintaining disease remission throughout pregnancy in women with inflammatory
bowel disease is of the utmost importance to decrease the risk of adverse outcome. In general, corticosteroids
are safe to use during pregnancy, but no data exist in the specific use of budesonide MMX.
We report four cases of budesonide MMX in pregnancy and pregnancy outcome.
Methods: Four women with inflammatory bowel disease experienced disease activity during pregnancy.
They were treated with budesonide MMX in an attempt to obtain clinical remission. Disease
activity was assessed through physician’s global assessment as well as lower endoscopy.
Results: Budesonide MMX proved effective in achieving remission in three out of four women. One woman
had an uncomplicated colectomy in the second trimester. All children were born normal for gestational age,
with no congenital abnormalities and have reached all their developmentalmilestones. The four children have
received vaccines according to the national immunization programwithout complications.
Conclusion: No adverse pregnancy outcomes were reported after the use of budesonide MMX. To our
knowledge, this is the first report on the safety of budesonide MMX treatment in pregnant women
with inflammatory bowel disease.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Gastroenterology
Vol/bind53
Nummer12
Sider (fra-til)1459-1462
Antal sider4
ISSN0036-5521
DOI
StatusUdgivet - 2018

    Forskningsområder

  • IBD, Pregnancy, Budesonide

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