Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

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  • Nathalie Kliemann, International Agency for Research on Cancer, Frankrig
  • Neil Murphy, International Agency for Research on Cancer, Frankrig
  • Vivian Viallon, International Agency for Research on Cancer, Frankrig
  • Heinz Freisling, International Agency for Research on Cancer, Frankrig
  • Konstantinos K Tsilidis, Imperial College London, University of Ioannina School of Medicine, Grækenland
  • Sabina Rinaldi, International Agency for Research on Cancer, Frankrig
  • Francesca Romana Mancini, Université Paris-Sud, Universite de Versailles, Université Paris-Saclay, Frankrig
  • Guy Fagherazzi, Université Paris-Sud, Universite de Versailles, Université Paris-Saclay, Frankrig
  • Marie-Christine Boutron-Ruault, Université Paris-Sud, Universite de Versailles, Université Paris-Saclay, Frankrig
  • Heiner Boeing, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, University of Potsdam, Tyskland
  • Giovanna Masala, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for cancer research, prevention and clinical network (ISPRO), Florence, Italy., Italien
  • Vittorio Krogh, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Italien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Maria Santucci de Magistris, AOU Federico II Naples, Italy., Italien
  • Bas Bueno-de-Mesquita, Imperial College London, National Institute for Public Health and the Environment (RIVM), University Medical Centre Utrecht, University of Malaya, Malaysia
  • Elisabete Weiderpass, International Agency for Research on Cancer, UiT-The Arctic University of Norway, Norge
  • Tilman Kühn, German Cancer Research Center (DKFZ), Tyskland
  • Rudolf Kaaks, German Cancer Research Center (DKFZ), Tyskland
  • Paula Jakszyn, Facultat de Ciències de la Salut Blanquerna, Universitat Ramon Llull, Barcelona, Spain., Cancer Epidemiology Research Program Catalan Institute of Oncology Barcelona Spain , Spanien
  • Daniel Redondo-Sánchez, CIBER Epidemiology and Public Health CIBERESP, Andalusian School of Public Health, Granada, Spain., Universidad de Granada, Spanien
  • Pilar Amiano, CIBER Epidemiology and Public Health CIBERESP, Public Health Division of Gipuzkoa, Spanien
  • Maria-Dolores Chirlaque, CIBER Epidemiology and Public Health (CIBERESP), Madrid, IMIB-Arrixaca, Spanien
  • Aurelio Barricarte Gurrea, CIBER Epidemiology and Public Health (CIBERESP), Madrid, Navarra Public Health Institute, Navarra Institute for Health Research (IdsSNA), Pamplona, Spain., Spanien
  • Ulrica Ericson, Lund University, Sverige
  • Isabel Drake, Lund University, Sverige
  • Therese Haugdahl Nøst, UiT-The Arctic University of Norway, Norge
  • Dagfinn Aune, Imperial College London, Bjørknes University College, Oslo University, Storbritannien
  • Anne M May, Department of Epidemiology, Julius Center Research Program Cancer, UMC Utrecht, The Netherlands., Holland
  • Anne Tjønneland, Danish Cancer Society Research Center, Danmark
  • Christina Catherine Dahm
  • Kim Overvad
  • Rosario Tumino, Cancer Registry and Histopathology Department, Azienda Sanitaria Provinciale (ASP) Ragusa, Italy., Italien
  • Jose Ramón Quirós, Public Health Directorate, Asturias, Spain., Spanien
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Anna Karakatsani, Hellenic Health Foundation, Athens, National and Kapodistrian University of Athens, Grækenland
  • Carlo La Vecchia, Hellenic Health Foundation, Athens, Università degli Studi di Milano, Italien
  • Lena Maria Nilsson, Umeå University, Sverige
  • Elio Riboli, Imperial College London, Storbritannien
  • Inge Huybrechts, International Agency for Research on Cancer, Frankrig
  • Marc J Gunter, International Agency for Research on Cancer, Frankrig

Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of estimated BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition. Estimated BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (Hazard Ratio per 1-standard deviation change in BMR [HR1-sd ]: 2.46; 95%CI 1.20; 5.03), and distal colon cancer (HR1-sd : 1.33; 95%CI 1.001; 1.77) among men, and with proximal colon (HR1-sd : 1.16; 95%CI 1.01; 1.35), pancreatic (HR1-sd : 1.37; 95%CI 1.13; 1.66), thyroid (HR1-sd : 1.65; 95%CI 1.33; 2.05), postmenopausal breast (HR1-sd : 1.17; 95%CI 1.11; 1.22), and endometrial (HR1-sd : 1.20; 95%CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind147
Nummer3
Sider (fra-til)648-661
Antal sider14
ISSN0020-7136
DOI
StatusUdgivet - aug. 2020

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This article is protected by copyright. All rights reserved.

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