Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons

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Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons. / Wiese, Maria; Bashmakov, Yuriy; Chalyk, Natalia; Nielsen, Dennis Sandris; Krych, Lukasz; Kot, Witold; Klochkov, Victor; Pristensky, Dmitry; Bandaletova, Tatyana; Chernyshova, Marina; Kyle, Nigel; Petyaev, Ivan.

I: BioMed Research International, Bind 2019, 4625279, 06.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Wiese, M, Bashmakov, Y, Chalyk, N, Nielsen, DS, Krych, L, Kot, W, Klochkov, V, Pristensky, D, Bandaletova, T, Chernyshova, M, Kyle, N & Petyaev, I 2019, 'Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons', BioMed Research International, bind 2019, 4625279. https://doi.org/10.1155/2019/4625279

APA

Wiese, M., Bashmakov, Y., Chalyk, N., Nielsen, D. S., Krych, L., Kot, W., Klochkov, V., Pristensky, D., Bandaletova, T., Chernyshova, M., Kyle, N., & Petyaev, I. (2019). Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons. BioMed Research International, 2019, [4625279]. https://doi.org/10.1155/2019/4625279

CBE

Wiese M, Bashmakov Y, Chalyk N, Nielsen DS, Krych L, Kot W, Klochkov V, Pristensky D, Bandaletova T, Chernyshova M, Kyle N, Petyaev I. 2019. Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons. BioMed Research International. 2019:Article 4625279. https://doi.org/10.1155/2019/4625279

MLA

Vancouver

Author

Wiese, Maria ; Bashmakov, Yuriy ; Chalyk, Natalia ; Nielsen, Dennis Sandris ; Krych, Lukasz ; Kot, Witold ; Klochkov, Victor ; Pristensky, Dmitry ; Bandaletova, Tatyana ; Chernyshova, Marina ; Kyle, Nigel ; Petyaev, Ivan. / Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons. I: BioMed Research International. 2019 ; Bind 2019.

Bibtex

@article{473a6d1c01bd4e31aad3c479877f2a30,
title = "Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons",
abstract = "Lycopene rich food and dark chocolate are among the best-documented products with a broad health benefit. This study explored the systemic effect of lycopene and dark chocolate (DC) on gut microbiota, blood, liver metabolism, skeletal muscle tissue oxygenation and skin. 30 volunteers were recruited for this trial, 15 women and 15 men with a mean age of 55 +/- 5.7 years and with moderate obesity, 30 <BMI <35kg/m(2). They were randomized and divided into five equal interventional groups: three received different formulations of lycopene, one of them with a 7mg daily dose and two with 30mg; another group was given 10g of DC with 7mg lycopene embedded into its matrix, and the last group received 10g DC. The trial was double-blinded for the three lycopene groups and separately for the 2 DC groups; the trial lasted for 1 month. By the end of the trial there were dose-dependent changes in the gut microbiota profile in all three lycopene groups with an increase of relative abundance of, e.g., Bifidobacterium adolescentis and Bifidobacterium longum. This was also accompanied by dose-dependent changes in the blood, liver metabolism, skeletal muscle and skin parameters. Consumption of DC resulted in increased relative abundance of, e.g., Lactobacillus and a reduction of corneocyte exfoliation. This is the first study which reports the prebiotic potential of lycopene and DC.",
keywords = "HEALTH, SUPPLEMENTATION, ANTIOXIDANTS, CONSUMPTION, PROBIOTICS, BACTERIA, DISEASE, MARKERS, LUTEIN, PCR",
author = "Maria Wiese and Yuriy Bashmakov and Natalia Chalyk and Nielsen, {Dennis Sandris} and Lukasz Krych and Witold Kot and Victor Klochkov and Dmitry Pristensky and Tatyana Bandaletova and Marina Chernyshova and Nigel Kyle and Ivan Petyaev",
year = "2019",
month = jun,
doi = "10.1155/2019/4625279",
language = "English",
volume = "2019",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons

AU - Wiese, Maria

AU - Bashmakov, Yuriy

AU - Chalyk, Natalia

AU - Nielsen, Dennis Sandris

AU - Krych, Lukasz

AU - Kot, Witold

AU - Klochkov, Victor

AU - Pristensky, Dmitry

AU - Bandaletova, Tatyana

AU - Chernyshova, Marina

AU - Kyle, Nigel

AU - Petyaev, Ivan

PY - 2019/6

Y1 - 2019/6

N2 - Lycopene rich food and dark chocolate are among the best-documented products with a broad health benefit. This study explored the systemic effect of lycopene and dark chocolate (DC) on gut microbiota, blood, liver metabolism, skeletal muscle tissue oxygenation and skin. 30 volunteers were recruited for this trial, 15 women and 15 men with a mean age of 55 +/- 5.7 years and with moderate obesity, 30 <BMI <35kg/m(2). They were randomized and divided into five equal interventional groups: three received different formulations of lycopene, one of them with a 7mg daily dose and two with 30mg; another group was given 10g of DC with 7mg lycopene embedded into its matrix, and the last group received 10g DC. The trial was double-blinded for the three lycopene groups and separately for the 2 DC groups; the trial lasted for 1 month. By the end of the trial there were dose-dependent changes in the gut microbiota profile in all three lycopene groups with an increase of relative abundance of, e.g., Bifidobacterium adolescentis and Bifidobacterium longum. This was also accompanied by dose-dependent changes in the blood, liver metabolism, skeletal muscle and skin parameters. Consumption of DC resulted in increased relative abundance of, e.g., Lactobacillus and a reduction of corneocyte exfoliation. This is the first study which reports the prebiotic potential of lycopene and DC.

AB - Lycopene rich food and dark chocolate are among the best-documented products with a broad health benefit. This study explored the systemic effect of lycopene and dark chocolate (DC) on gut microbiota, blood, liver metabolism, skeletal muscle tissue oxygenation and skin. 30 volunteers were recruited for this trial, 15 women and 15 men with a mean age of 55 +/- 5.7 years and with moderate obesity, 30 <BMI <35kg/m(2). They were randomized and divided into five equal interventional groups: three received different formulations of lycopene, one of them with a 7mg daily dose and two with 30mg; another group was given 10g of DC with 7mg lycopene embedded into its matrix, and the last group received 10g DC. The trial was double-blinded for the three lycopene groups and separately for the 2 DC groups; the trial lasted for 1 month. By the end of the trial there were dose-dependent changes in the gut microbiota profile in all three lycopene groups with an increase of relative abundance of, e.g., Bifidobacterium adolescentis and Bifidobacterium longum. This was also accompanied by dose-dependent changes in the blood, liver metabolism, skeletal muscle and skin parameters. Consumption of DC resulted in increased relative abundance of, e.g., Lactobacillus and a reduction of corneocyte exfoliation. This is the first study which reports the prebiotic potential of lycopene and DC.

KW - HEALTH

KW - SUPPLEMENTATION

KW - ANTIOXIDANTS

KW - CONSUMPTION

KW - PROBIOTICS

KW - BACTERIA

KW - DISEASE

KW - MARKERS

KW - LUTEIN

KW - PCR

U2 - 10.1155/2019/4625279

DO - 10.1155/2019/4625279

M3 - Journal article

VL - 2019

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 4625279

ER -