Abstract
Background. General anesthetics are used extensively in modern medicine, but the associated cardiopulmonary risks and chronic neural effects pose a growing issue to aging patient populations. Anesthetic premedication presents a promising method to reduce the risks associated with high-dose general anesthesia.
Methods. The present study was designed to probe the anesthetic sparing properties of acute vagus nerve blockade in mice. To this end, we treated the vagus nerve with either bupivacaine or saline (control) via a pre-installed neck catheter one hour prior to isoflurane gas anesthesia. We assessed the anesthetic potency by computing the anesthetic induction time using a deep learning-based method for pose estimation.
Results. When preceded by vagus nerve blockade, the induction time of isoflurane gas anesthesia decreased by 22% (-15 seconds, P < 0.05), consistent with anesthetic potentiation. In addition, vagus nerve blockade exhibited hemodynamic stabilizing effects. Potential confounders, such as age, had minor significance.
Conclusion. Vagus nerve blockade may be an effective general anesthetic adjuvant with hemodynamic stabilizing effects. Further research is needed to confirm the findings presented in this preliminary study, e.g., using targeted vagus nerve blockade and extensive hemodynamic monitoring.
Methods. The present study was designed to probe the anesthetic sparing properties of acute vagus nerve blockade in mice. To this end, we treated the vagus nerve with either bupivacaine or saline (control) via a pre-installed neck catheter one hour prior to isoflurane gas anesthesia. We assessed the anesthetic potency by computing the anesthetic induction time using a deep learning-based method for pose estimation.
Results. When preceded by vagus nerve blockade, the induction time of isoflurane gas anesthesia decreased by 22% (-15 seconds, P < 0.05), consistent with anesthetic potentiation. In addition, vagus nerve blockade exhibited hemodynamic stabilizing effects. Potential confounders, such as age, had minor significance.
Conclusion. Vagus nerve blockade may be an effective general anesthetic adjuvant with hemodynamic stabilizing effects. Further research is needed to confirm the findings presented in this preliminary study, e.g., using targeted vagus nerve blockade and extensive hemodynamic monitoring.
| Originalsprog | Engelsk |
|---|---|
| Publikationsdato | okt. 2023 |
| Status | Udgivet - okt. 2023 |
| Begivenhed | 6th Annual Research Meeting: at the Department of Clinical Medicine in Aarhus - Aarhus Universitet, Aarhus N, Danmark Varighed: 31 okt. 2023 → 31 okt. 2023 |
Andet
| Andet | 6th Annual Research Meeting |
|---|---|
| Lokation | Aarhus Universitet |
| Land/Område | Danmark |
| By | Aarhus N |
| Periode | 31/10/2023 → 31/10/2023 |