Porcine SLITRK1: Molecular cloning and characterization

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Porcine SLITRK1 : Molecular cloning and characterization. / Larsen, Knud Erik; Momeni, Jamal; Farajzadeh, Leila; Bendixen, Christian.

I: F E B S Open Bio, Bind 4, 10.2014, s. 872-878.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{9055d192602b4afeaaaba5735a96d7c8,
title = "Porcine SLITRK1: Molecular cloning and characterization",
abstract = "The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns, as does its human and mouse counterparts. RT-PCR cloning revealed two SLITRK1 transcripts: a full-length mRNA and a transcript variant that results in a truncated protein. The encoded SLITRK1 protein, consisting of 695 amino acids, displays a very high homology to human SLITRK1 (99{\%}). The porcine SLITRK1 gene is expressed exclusively in brain tissues.",
keywords = "ADHD, attention deficit hyperactivity disorder, LRR, leucine-rich repeats, OCD, obsessive–compulsive disorder, TS, Tourette syndrome",
author = "Larsen, {Knud Erik} and Jamal Momeni and Leila Farajzadeh and Christian Bendixen",
year = "2014",
month = "10",
doi = "10.1016/j.fob.2014.10.001",
language = "English",
volume = "4",
pages = "872--878",
journal = "F E B S Open Bio",
issn = "2211-5463",
publisher = "FEBS Press",

}

RIS

TY - JOUR

T1 - Porcine SLITRK1

T2 - Molecular cloning and characterization

AU - Larsen, Knud Erik

AU - Momeni, Jamal

AU - Farajzadeh, Leila

AU - Bendixen, Christian

PY - 2014/10

Y1 - 2014/10

N2 - The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns, as does its human and mouse counterparts. RT-PCR cloning revealed two SLITRK1 transcripts: a full-length mRNA and a transcript variant that results in a truncated protein. The encoded SLITRK1 protein, consisting of 695 amino acids, displays a very high homology to human SLITRK1 (99%). The porcine SLITRK1 gene is expressed exclusively in brain tissues.

AB - The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns, as does its human and mouse counterparts. RT-PCR cloning revealed two SLITRK1 transcripts: a full-length mRNA and a transcript variant that results in a truncated protein. The encoded SLITRK1 protein, consisting of 695 amino acids, displays a very high homology to human SLITRK1 (99%). The porcine SLITRK1 gene is expressed exclusively in brain tissues.

KW - ADHD, attention deficit hyperactivity disorder

KW - LRR, leucine-rich repeats

KW - OCD, obsessive–compulsive disorder

KW - TS, Tourette syndrome

U2 - 10.1016/j.fob.2014.10.001

DO - 10.1016/j.fob.2014.10.001

M3 - Journal article

C2 - 25379384

VL - 4

SP - 872

EP - 878

JO - F E B S Open Bio

JF - F E B S Open Bio

SN - 2211-5463

ER -