Population genomics of ancient and modern Trichuris trichiura

Stephen R. Doyle; Martin Jensen Søe; Peter Nejsum; Martha Betson; Philip J. Cooper; Lifei Peng; Xing Quan Zhu; Ana Sanchez; Gabriela Matamoros; Gustavo Adolfo Fontecha Sandoval; Cristina Cutillas; Louis Albert Tchuem Tchuenté; Zeleke Mekonnen; Shaali M. Ame; Harriet Namwanje; Bruno Levecke; Matthew Berriman; Brian Lund Fredensborg; Christian Moliin Outzen Kapel

doi:10.1038/s41467-022-31487-x

Population genomics of ancient and modern Trichuris trichiura

Stephen R. Doyle^*, Martin Jensen Søe, Peter Nejsum, Martha Betson, Philip J. Cooper, Lifei Peng, Xing Quan Zhu, Ana Sanchez, Gabriela Matamoros, Gustavo Adolfo Fontecha Sandoval, Cristina Cutillas, Louis Albert Tchuem Tchuenté, Zeleke Mekonnen, Shaali M. Ame, Harriet Namwanje, Bruno Levecke, Matthew Berriman, Brian Lund Fredensborg, Christian Moliin Outzen Kapel

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin - Infektionssygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura. We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth.

Originalsprog	Engelsk
Artikelnummer	3888
Tidsskrift	Nature Communications
Vol/bind	13
Nummer	1
Antal sider	12
ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-022-31487-x
Status	Udgivet - dec. 2022

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10.1038/s41467-022-31487-xLicens: CC BY

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Doyle, S. R., Søe, M. J., Nejsum, P., Betson, M., Cooper, P. J., Peng, L., Zhu, X. Q., Sanchez, A., Matamoros, G., Sandoval, G. A. F., Cutillas, C., Tchuenté, L. A. T., Mekonnen, Z., Ame, S. M., Namwanje, H., Levecke, B., Berriman, M., Fredensborg, B. L., & Kapel, C. M. O. (2022). Population genomics of ancient and modern Trichuris trichiura. Nature Communications, 13(1), Artikel 3888. https://doi.org/10.1038/s41467-022-31487-x

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title = "Population genomics of ancient and modern Trichuris trichiura",

abstract = "The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura. We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth.",

author = "Doyle, {Stephen R.} and S{\o}e, {Martin Jensen} and Peter Nejsum and Martha Betson and Cooper, {Philip J.} and Lifei Peng and Zhu, {Xing Quan} and Ana Sanchez and Gabriela Matamoros and Sandoval, {Gustavo Adolfo Fontecha} and Cristina Cutillas and Tchuent{\'e}, {Louis Albert Tchuem} and Zeleke Mekonnen and Ame, {Shaali M.} and Harriet Namwanje and Bruno Levecke and Matthew Berriman and Fredensborg, {Brian Lund} and Kapel, {Christian Moliin Outzen}",

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Doyle, SR, Søe, MJ, Nejsum, P, Betson, M, Cooper, PJ, Peng, L, Zhu, XQ, Sanchez, A, Matamoros, G, Sandoval, GAF, Cutillas, C, Tchuenté, LAT, Mekonnen, Z, Ame, SM, Namwanje, H, Levecke, B, Berriman, M, Fredensborg, BL & Kapel, CMO 2022, 'Population genomics of ancient and modern Trichuris trichiura', Nature Communications, bind 13, nr. 1, 3888. https://doi.org/10.1038/s41467-022-31487-x

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AU - Tchuenté, Louis Albert Tchuem

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AU - Ame, Shaali M.

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N2 - The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura. We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth.

AB - The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura. We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth.

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Population genomics of ancient and modern Trichuris trichiura

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