Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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  • Raul Zamora-Ros, Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Valerie Cayssials, Departamento de Bioestadística, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay., Uruguay
  • Silvia Franceschi, CRO Aviano National Cancer Institute IRCCS, Aviano, Italy., Italien
  • Cecilie Kyrø, Diet, Genes and Environment Unit, Danish Cancer Society Research Center, Copenhagen, Denmark., Danmark
  • Elisabete Weiderpass, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Joakim Hennings, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden., Sverige
  • Maria Sandström, Department of Radiation Sciences and Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Sverige
  • Anne Tjønneland, Diet, Genes and Environment Unit, Danish Cancer Society Research Center, Copenhagen, Denmark., Danmark
  • Anja Olsen, Kræftens Bekæmpelse, Danmark
  • Kim Overvad
  • Marie-Christine Boutron-Ruault, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Thérèse Truong, INSERM, Center for Research in Epidemiology and Population Health (CESP), Cancer and Environment Team, Université Paris-Sud, Université Paris-Saclay, Villejuif, France., Frankrig
  • Francesca Romana Mancini, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Verena Katzke, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Tyskland
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Anna Karakatsani, 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Grækenland
  • Georgia Martimianaki, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Domenico Palli, Cancer Risk Factors and Life-Style Epidemiology Unit. Institute for Cancer Research, Prevention and Clinical Network - ISPRO, 50141, Florence, Italy., Italien
  • Vittorio Krogh, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Salvatore Panico, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Unit "Civic - M.P. Arezzo "Hospital ASP Ragusa, Italy., Italien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Cristina Lasheras, Department of Functional Biology, Faculty of Medicine, University of Oviedo, CP 33006 Oviedo, Asturias, Spain., Spanien
  • Miguel Rodríguez-Barranco, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Spanien
  • Pilar Amiano, Public Health Division of Gipuzkoa, Basque Government, Spain; Health Research Institute, Biodonostia, San Sebastián, Spain., Spanien
  • Sandra M Colorado-Yohar, Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia., Colombia
  • Eva Ardanaz, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Spanien
  • Martin Almquist, Department of Surgery, Lund University, Skåne University Hospital, Malmö, Sweden, Sverige
  • Ulrika Ericson, Lund University, Sverige
  • H Bas Bueno-de-Mesquita, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia., Malaysia
  • Roel Vermeulen, 1] School of Public Health, Imperial College, London, UK [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Holland
  • Julie A Schmidt, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom., Storbritannien
  • Graham Byrnes, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Augustin Scalbert, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Antonio Agudo, Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Sabina Rinaldi, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig

Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77-1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80-1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55-2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind146
Nummer7
Sider (fra-til)1841-1850
Antal sider10
ISSN0020-7136
DOI
StatusUdgivet - 2020

Bibliografisk note

© 2019 UICC.

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