Aarhus University Seal / Aarhus Universitets segl

Polycation-based nanoparticle delivery for improved RNA interference therapeutics

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Small-interfering RNA (siRNA)-mediated silencing of genes implicated in disease by the process of RNA interference offers a novel genetic medicine approach. Polymeric nanoparticles (or polyplexes) formed by self-assembly of polycations with siRNA can be used for site-specific delivery, cellular uptake and intracellular trafficking as a strategy to improve the therapeutic potential of siRNA. This review describes the application of polyplexes for in vivo delivery of synthetic siRNA with focus given to systemic and mucosal routes and in vivo requirements. Issues including use of stimuli-responsive systems for intracellular trafficking of siRNA are discussed as part of necessary future directives towards the development of RNA-based clinical therapeutics.
TidsskriftExpert opinion on biological therapy
Sider (fra-til)1811-1822
Antal sider12
StatusUdgivet - 2007

Se relationer på Aarhus Universitet Citationsformater

ID: 44941918