Plasticity in corticomotor pathways linked to a jaw protrusion training task: Potential implications for management of patients with obstructive sleep apnea

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  • Takashi Iida, Nihon University School of Dentistry at Matsudo
  • ,
  • Mohit Kothari
  • Satoshi Sekihata, Nihon University School of Dentistry at Matsudo
  • ,
  • Akiko Shimada, Osaka Dental University
  • ,
  • Osamu Komiyama, Nihon University School of Dentistry at Matsudo, Japan
  • Peter Svensson
The aim of the study was to investigate the effect of a standardized and repeated jaw protrusion training (JPT) task on corticomotor excitability as assessed by motor evoked potentials (MEPs) in the masseter and tongue muscle with the use of transcranial magnetic stimulation (TMS). Sixteen healthy participants performed three series of a standardized JPT task on three consecutive days. Each day participants performed 41 min of JPT consisting of three series. In all three series, participants were instructed to target 50% and 100% of the maximum jaw protrusion positions. In the first and third series without any feedback but during during the second series, participants were provided a custom-made mandibular advancement device to help achieve the correct protruded position. Single pulse TMS was applied to elicit MEPs from right masseter, right tongue and right first dorsal interosseous muscles (FDI) (as control), pre and post-task on Day 1 and 3. There was no significant difference in masseter EMG activities during 50% and 100% JPT between session or time (day). Masseter MEPs and tongue MEPs were significantly dependent on stimulus intensity (P < 0.001) and on task session (P < 0.001). The amplitude of masseter and tongue MEPs at post-task Day 3 were significantly higher compared to baseline values (pre-task Day 1) (P < 0.005). In contrast, FDI MEPs were dependent on stimulus intensity only (P < 0.001) but not on task session (P = 0.677). Our novel findings suggest that participants performing an active and repeated JPT task demonstrate neuroplasticity in terms of increased corticomotor excitability not only in the masseter muscles but also in the tongue muscles. This finding may have implications for patients with obstructive sleep apnea treated by a mandibular advancement device where the lower jaw is passively held in a protruded position.
OriginalsprogEngelsk
Artikelnummer147124
TidsskriftBrain Research
Vol/bind1749
Antal sider9
ISSN0006-8993
DOI
StatusUdgivet - dec. 2020

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