Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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  • Laura M Harms, Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany., Tyskland
  • Augustin Scalbert, Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France., Frankrig
  • Raul Zamora-Ros, Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Sabina Rinaldi, Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France., Frankrig
  • Mazda Jenab, Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France., Frankrig
  • Neil Murphy, Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • ,
  • David Achaintre, Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France., Frankrig
  • Anne Tjønneland, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Danmark
  • Anja Olsen
  • Kim Overvad
  • Francesca Romana Mancini, Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM UMRS 1018, Villejuif F-94805, France., Frankrig
  • Yahya Mahamat-Saleh, Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM UMRS 1018, Villejuif F-94805, France., Frankrig
  • Marie-Christine Boutron-Ruault, Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM UMRS 1018, Villejuif F-94805, France., Frankrig
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. r.kaaks@dkfz-heidelberg.de., Tyskland
  • Verena Katzke, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. r.kaaks@dkfz-heidelberg.de., Tyskland
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Greece., Grækenland
  • Georgia Martimianaki, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Anna Karakatsani, 2nd Pulmonary Medicine Department, School of Medicine, National and KapodistrianUniversity of Athens, "ATTIKON" University Hospital, Haidari, Greece., Grækenland
  • Domenico Palli, 15 Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy., Italien
  • Salvatore Panico, EPIC Centre of Naples. Dipartimento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy., Italien
  • Sabina Sieri, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Unit "Civic - M.P. Arezzo "Hospital ASP Ragusa, Italy., Italien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Bas Bueno-de-Mesquita, Department of Social and Preventative Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Malaysia
  • Roel C H Vermeulen, Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Holland
  • Elisabete Weiderpass, Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France., Frankrig
  • Therese Haugdahl Nøst, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway., Norge
  • Cristina Lasheras, Department of Functional Biology, Faculty of Medicine, University of Oviedo, CP 33006 Oviedo, Asturias, Spain., Spanien
  • Miguel Rodríguez-Barranco, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Spanien
  • José María Huerta, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Spanien
  • Aurelio Barricarte, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Spanien
  • Miren Dorronsoro, Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain., Spanien
  • Johan Hultdin, Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden, Sverige
  • Julie A Schmidt, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Marc Gunter, Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization, Lyon, France., Frankrig
  • Elio Riboli, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; MRC-PHE Centre for Environment, School of Public Health, Imperial College London, London, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Grækenland
  • Krasimira Aleksandrova, University of Potsdam, Institute of Nutritional Science, Potsdam, Germany., Tyskland

Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent, and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterize the association between plasma concentrations of 35 polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis the odds and 95% confidence intervals (CI-s) of elevated serum hsCRP (>3 mg/L) were calculated within quartiles and per standard deviation (SD) higher level of plasma polyphenol concentrations. In multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per SD) was associated with 29% lower odds of elevated hsCRP (95% CI: 50%-1%). In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR= 0.66, 95%CI 0.46-0.96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR=0.58, 95%CI 0.39-0.86), 3,4-dihydroxyphenylpropionic acid (OR= 0.63, 95% CI 0.46-0.87), ferulic acid (OR= 0.65, 95%CI 0.44-0.96), and caffeic acid (OR= 0.69, 95%CI 0.51-0.93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR= 0.67, 95%CI 0.48-0.93). This study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.

OriginalsprogEngelsk
Artikelnummer0007114519002538
TidsskriftThe British Journal of Nutrition
Vol/bind123
Nummer2
Sider (fra-til)198-208
Antal sider11
ISSN0007-1145
DOI
StatusUdgivet - 2020

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