Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women

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Plasma CD36 and Incident Diabetes : A Case-Cohort Study in Danish Men and Women. / Wang, Yeli; Zhu, Jingwen; Aroner, Sarah; Overvad, Kim; Cai, Tianxi; Yang, Ming; Tjønneland, Anne; Handberg, Aase; Jensen, Majken K.

I: Diabetes Metab, Bind 44, Nr. 1, e46, 02.2020, s. 134-142.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Wang, Y, Zhu, J, Aroner, S, Overvad, K, Cai, T, Yang, M, Tjønneland, A, Handberg, A & Jensen, MK 2020, 'Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women', Diabetes Metab, bind 44, nr. 1, e46, s. 134-142. https://doi.org/10.4093/dmj.2018.0273

APA

Wang, Y., Zhu, J., Aroner, S., Overvad, K., Cai, T., Yang, M., Tjønneland, A., Handberg, A., & Jensen, M. K. (2020). Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women. Diabetes Metab, 44(1), 134-142. [e46]. https://doi.org/10.4093/dmj.2018.0273

CBE

Wang Y, Zhu J, Aroner S, Overvad K, Cai T, Yang M, Tjønneland A, Handberg A, Jensen MK. 2020. Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women. Diabetes Metab. 44(1):134-142. https://doi.org/10.4093/dmj.2018.0273

MLA

Vancouver

Wang Y, Zhu J, Aroner S, Overvad K, Cai T, Yang M o.a. Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women. Diabetes Metab. 2020 feb;44(1):134-142. e46. https://doi.org/10.4093/dmj.2018.0273

Author

Wang, Yeli ; Zhu, Jingwen ; Aroner, Sarah ; Overvad, Kim ; Cai, Tianxi ; Yang, Ming ; Tjønneland, Anne ; Handberg, Aase ; Jensen, Majken K. / Plasma CD36 and Incident Diabetes : A Case-Cohort Study in Danish Men and Women. I: Diabetes Metab. 2020 ; Bind 44, Nr. 1. s. 134-142.

Bibtex

@article{3877b062fe14485b928bd4afee4f7522,
title = "Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women",
abstract = "BACKGROUND: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).RESULTS: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.CONCLUSION: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.",
keywords = "adiposity, biomarkers, CD36 antigens, diabetes mellitus, type 2, epidemiology, prospective studies",
author = "Yeli Wang and Jingwen Zhu and Sarah Aroner and Kim Overvad and Tianxi Cai and Ming Yang and Anne Tj{\o}nneland and Aase Handberg and Jensen, {Majken K}",
note = "Copyright {\textcopyright} 2020 Korean Diabetes Association.",
year = "2020",
month = feb,
doi = "10.4093/dmj.2018.0273",
language = "English",
volume = "44",
pages = "134--142",
journal = "Diabetes Metab",
issn = "2233-6079",
publisher = "Korean Diabetes Association",
number = "1",

}

RIS

TY - JOUR

T1 - Plasma CD36 and Incident Diabetes

T2 - A Case-Cohort Study in Danish Men and Women

AU - Wang, Yeli

AU - Zhu, Jingwen

AU - Aroner, Sarah

AU - Overvad, Kim

AU - Cai, Tianxi

AU - Yang, Ming

AU - Tjønneland, Anne

AU - Handberg, Aase

AU - Jensen, Majken K

N1 - Copyright © 2020 Korean Diabetes Association.

PY - 2020/2

Y1 - 2020/2

N2 - BACKGROUND: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).RESULTS: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.CONCLUSION: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.

AB - BACKGROUND: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).RESULTS: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.CONCLUSION: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.

KW - adiposity

KW - biomarkers

KW - CD36 antigens

KW - diabetes mellitus, type 2

KW - epidemiology

KW - prospective studies

U2 - 10.4093/dmj.2018.0273

DO - 10.4093/dmj.2018.0273

M3 - Journal article

C2 - 31701685

VL - 44

SP - 134

EP - 142

JO - Diabetes Metab

JF - Diabetes Metab

SN - 2233-6079

IS - 1

M1 - e46

ER -