Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women

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DOI

  • Yeli Wang, Health Services and Systems Research, Duke-NUS (National University of Singapore) Medical School, Singapore., Singapore
  • Jingwen Zhu, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., USA
  • Sarah Aroner, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., USA
  • Kim Overvad
  • Tianxi Cai, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., USA
  • Ming Yang, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., USA
  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Aase Handberg, Klinisk Medicin, Aalborg Universitet
  • ,
  • Majken K Jensen, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

BACKGROUND: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.

METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).

RESULTS: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.

CONCLUSION: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.

OriginalsprogEngelsk
Artikelnummere46
TidsskriftDiabetes Metab
Vol/bind44
Nummer1
Sider (fra-til)134-142
Antal sider9
ISSN2233-6079
DOI
StatusUdgivet - feb. 2020

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