Placental mosaicism in the era of chromosomal microarrays

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Placental mosaicism in the era of chromosomal microarrays. / Vogel, Ida; Vestergaard, Else Marie; Lildballe, Dorte Launtoft; Christensen, Rikke; Hoseth, Gerd Eva; Petersen, Astrid Christine; Bogaard, Pauline; Sørensen, Anne Nødgaard.

I: European Journal of Medical Genetics, 2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Vogel, I, Vestergaard, EM, Lildballe, DL, Christensen, R, Hoseth, GE, Petersen, AC, Bogaard, P & Sørensen, AN 2019, 'Placental mosaicism in the era of chromosomal microarrays', European Journal of Medical Genetics. https://doi.org/10.1016/j.ejmg.2019.103778

APA

Vogel, I., Vestergaard, E. M., Lildballe, D. L., Christensen, R., Hoseth, G. E., Petersen, A. C., ... Sørensen, A. N. (2019). Placental mosaicism in the era of chromosomal microarrays. European Journal of Medical Genetics, [103778]. https://doi.org/10.1016/j.ejmg.2019.103778

CBE

Vogel I, Vestergaard EM, Lildballe DL, Christensen R, Hoseth GE, Petersen AC, Bogaard P, Sørensen AN. 2019. Placental mosaicism in the era of chromosomal microarrays. European Journal of Medical Genetics. https://doi.org/10.1016/j.ejmg.2019.103778

MLA

Vancouver

Vogel I, Vestergaard EM, Lildballe DL, Christensen R, Hoseth GE, Petersen AC o.a. Placental mosaicism in the era of chromosomal microarrays. European Journal of Medical Genetics. 2019. 103778. https://doi.org/10.1016/j.ejmg.2019.103778

Author

Vogel, Ida ; Vestergaard, Else Marie ; Lildballe, Dorte Launtoft ; Christensen, Rikke ; Hoseth, Gerd Eva ; Petersen, Astrid Christine ; Bogaard, Pauline ; Sørensen, Anne Nødgaard. / Placental mosaicism in the era of chromosomal microarrays. I: European Journal of Medical Genetics. 2019.

Bibtex

@article{cc1fd783d8ad4fd892e38c326e0f5672,
title = "Placental mosaicism in the era of chromosomal microarrays",
abstract = "Objective: Placental mosaicism for a subset of a chromosome, a structural chromosomal aberration, is thought to be a very rare finding in chorionic villus samples. Here, we present clinical and laboratory data on five cases with such mosaicism for structural chromosomal aberrations. Methods: During a period of 6 months, chromosomal microarray was carried out on DNA extracted from 100 uncultured chorion villous samples from high-risk pregnancies. Results: In five of 100 consecutively collected samples (5/100), mosaicism for a structural chromosomal aberration was detected. The mosaic aberration was subsequently detected in fetal tissue in three of the five cases. Conclusion: Chromosomal microarray can detect placental mosaicism for structural chromosomal aberrations. This kind of mosaicism may be more frequent than previously anticipated, and the fetal involvement seems difficult to predict. These findings highlight the complexity of mosaicism for structural chromosomal aberrations in prenatal samples in the chromosomal microarray era.",
keywords = "Chorionic villus sampling, Mosaicism, Placenta, Prenatal diagnosis, Structural chromosomal abnormality",
author = "Ida Vogel and Vestergaard, {Else Marie} and Lildballe, {Dorte Launtoft} and Rikke Christensen and Hoseth, {Gerd Eva} and Petersen, {Astrid Christine} and Pauline Bogaard and S{\o}rensen, {Anne N{\o}dgaard}",
year = "2019",
doi = "10.1016/j.ejmg.2019.103778",
language = "English",
journal = "European Journal of Medical Genetics",
issn = "1769-7212",
publisher = "Elsevier Masson",

}

RIS

TY - JOUR

T1 - Placental mosaicism in the era of chromosomal microarrays

AU - Vogel, Ida

AU - Vestergaard, Else Marie

AU - Lildballe, Dorte Launtoft

AU - Christensen, Rikke

AU - Hoseth, Gerd Eva

AU - Petersen, Astrid Christine

AU - Bogaard, Pauline

AU - Sørensen, Anne Nødgaard

PY - 2019

Y1 - 2019

N2 - Objective: Placental mosaicism for a subset of a chromosome, a structural chromosomal aberration, is thought to be a very rare finding in chorionic villus samples. Here, we present clinical and laboratory data on five cases with such mosaicism for structural chromosomal aberrations. Methods: During a period of 6 months, chromosomal microarray was carried out on DNA extracted from 100 uncultured chorion villous samples from high-risk pregnancies. Results: In five of 100 consecutively collected samples (5/100), mosaicism for a structural chromosomal aberration was detected. The mosaic aberration was subsequently detected in fetal tissue in three of the five cases. Conclusion: Chromosomal microarray can detect placental mosaicism for structural chromosomal aberrations. This kind of mosaicism may be more frequent than previously anticipated, and the fetal involvement seems difficult to predict. These findings highlight the complexity of mosaicism for structural chromosomal aberrations in prenatal samples in the chromosomal microarray era.

AB - Objective: Placental mosaicism for a subset of a chromosome, a structural chromosomal aberration, is thought to be a very rare finding in chorionic villus samples. Here, we present clinical and laboratory data on five cases with such mosaicism for structural chromosomal aberrations. Methods: During a period of 6 months, chromosomal microarray was carried out on DNA extracted from 100 uncultured chorion villous samples from high-risk pregnancies. Results: In five of 100 consecutively collected samples (5/100), mosaicism for a structural chromosomal aberration was detected. The mosaic aberration was subsequently detected in fetal tissue in three of the five cases. Conclusion: Chromosomal microarray can detect placental mosaicism for structural chromosomal aberrations. This kind of mosaicism may be more frequent than previously anticipated, and the fetal involvement seems difficult to predict. These findings highlight the complexity of mosaicism for structural chromosomal aberrations in prenatal samples in the chromosomal microarray era.

KW - Chorionic villus sampling

KW - Mosaicism

KW - Placenta

KW - Prenatal diagnosis

KW - Structural chromosomal abnormality

UR - http://www.scopus.com/inward/record.url?scp=85072820072&partnerID=8YFLogxK

U2 - 10.1016/j.ejmg.2019.103778

DO - 10.1016/j.ejmg.2019.103778

M3 - Journal article

C2 - 31580923

AN - SCOPUS:85072820072

JO - European Journal of Medical Genetics

JF - European Journal of Medical Genetics

SN - 1769-7212

M1 - 103778

ER -