Placental baseline conditions modulate the hyperoxic BOLD-MRI response

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Placental baseline conditions modulate the hyperoxic BOLD-MRI response. / Sinding, Marianne; Peters, David A.; Poulsen, Sofie S.; Frøkjær, Jens B.; Christiansen, Ole B.; Petersen, Astrid; Uldbjerg, Niels; Sørensen, Anne.

I: Placenta, Bind 61, Nr. 1, 01.01.2018, s. 17-23.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Sinding, M, Peters, DA, Poulsen, SS, Frøkjær, JB, Christiansen, OB, Petersen, A, Uldbjerg, N & Sørensen, A 2018, 'Placental baseline conditions modulate the hyperoxic BOLD-MRI response', Placenta, bind 61, nr. 1, s. 17-23. https://doi.org/10.1016/j.placenta.2017.11.002

APA

Sinding, M., Peters, D. A., Poulsen, S. S., Frøkjær, J. B., Christiansen, O. B., Petersen, A., ... Sørensen, A. (2018). Placental baseline conditions modulate the hyperoxic BOLD-MRI response. Placenta, 61(1), 17-23. https://doi.org/10.1016/j.placenta.2017.11.002

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Author

Sinding, Marianne ; Peters, David A. ; Poulsen, Sofie S. ; Frøkjær, Jens B. ; Christiansen, Ole B. ; Petersen, Astrid ; Uldbjerg, Niels ; Sørensen, Anne. / Placental baseline conditions modulate the hyperoxic BOLD-MRI response. I: Placenta. 2018 ; Bind 61, Nr. 1. s. 17-23.

Bibtex

@article{0fc10803ad6040c4938ae19fffb981f5,
title = "Placental baseline conditions modulate the hyperoxic BOLD-MRI response",
abstract = "Objectives: Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*).Method: We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight <10th percentile in combination with placental pathological signs of vascular malperfusion. During maternal oxygen inhalation, we measured the relative Delta BOLD response ((hyperoxic BOLD - baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute Delta T2* (hyperoxic T2* - baseline T2*) from breath-hold multi-echo GRE sequences.Results: In the control group, the relative Delta BOLD response increased during gestation from 5{\%} in gestational week 20 to 20{\%} in week 40. In the case group, the relative Delta BOLD response was significantly higher (mean Z-score 4.94; 95{\%} CI 2.41, 7.47). The absolute Delta T2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score - 3.13;95{\%} CI -3.94, - 2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log(10) DBOLD response and the baseline T2* (r = -0.88, p <0.0001).Conclusion: The high hyperoxic DBOLD response demonstrated in pregnancies complicated by placental dysfunction may simply reflect altered baseline conditions, as the absolute increase in placental oxygenation (Delta T2*) does not differ between groups. (c) 2017 Elsevier Ltd. All rights reserved.",
keywords = "BOLD MRI, Magnetic resonance imaging, Placental dysfunction, Placental oxygenation, T2* relaxation, 1.5 T, FETAL ARTERIAL, OXYGENATION, PULSATILITY INDEX, T2*relaxation, PHYSIOLOGICAL-BASIS, MAGNETIC-RESONANCE, RELAXATION-TIME MEASUREMENTS, GROWTH RESTRICTION, BLOOD, PRIMATE PLACENTA, Pregnancy Trimester, Second, Up-Regulation, Humans, Hyperoxia/diagnostic imaging, Pregnancy Trimester, Third, Case-Control Studies, Placenta/blood supply, Placental Circulation, Adult, Female, Severity of Illness Index, Reproducibility of Results, Vascular Resistance, Placentation, Prenatal Diagnosis, Magnetic Resonance Angiography, Fetal Growth Retardation/etiology, Pregnancy Complications, Cardiovascular/diagnostic imaging, Peripheral Vascular Diseases/diagnostic imaging, Pregnancy, Magnetic Resonance Imaging, Placenta Diseases/diagnostic imaging",
author = "Marianne Sinding and Peters, {David A.} and Poulsen, {Sofie S.} and Fr{\o}kj{\ae}r, {Jens B.} and Christiansen, {Ole B.} and Astrid Petersen and Niels Uldbjerg and Anne S{\o}rensen",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.placenta.2017.11.002",
language = "English",
volume = "61",
pages = "17--23",
journal = "Placenta",
issn = "0143-4004",
publisher = "Elsevier Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Placental baseline conditions modulate the hyperoxic BOLD-MRI response

AU - Sinding, Marianne

AU - Peters, David A.

AU - Poulsen, Sofie S.

AU - Frøkjær, Jens B.

AU - Christiansen, Ole B.

AU - Petersen, Astrid

AU - Uldbjerg, Niels

AU - Sørensen, Anne

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*).Method: We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight <10th percentile in combination with placental pathological signs of vascular malperfusion. During maternal oxygen inhalation, we measured the relative Delta BOLD response ((hyperoxic BOLD - baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute Delta T2* (hyperoxic T2* - baseline T2*) from breath-hold multi-echo GRE sequences.Results: In the control group, the relative Delta BOLD response increased during gestation from 5% in gestational week 20 to 20% in week 40. In the case group, the relative Delta BOLD response was significantly higher (mean Z-score 4.94; 95% CI 2.41, 7.47). The absolute Delta T2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score - 3.13;95% CI -3.94, - 2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log(10) DBOLD response and the baseline T2* (r = -0.88, p <0.0001).Conclusion: The high hyperoxic DBOLD response demonstrated in pregnancies complicated by placental dysfunction may simply reflect altered baseline conditions, as the absolute increase in placental oxygenation (Delta T2*) does not differ between groups. (c) 2017 Elsevier Ltd. All rights reserved.

AB - Objectives: Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*).Method: We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight <10th percentile in combination with placental pathological signs of vascular malperfusion. During maternal oxygen inhalation, we measured the relative Delta BOLD response ((hyperoxic BOLD - baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute Delta T2* (hyperoxic T2* - baseline T2*) from breath-hold multi-echo GRE sequences.Results: In the control group, the relative Delta BOLD response increased during gestation from 5% in gestational week 20 to 20% in week 40. In the case group, the relative Delta BOLD response was significantly higher (mean Z-score 4.94; 95% CI 2.41, 7.47). The absolute Delta T2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score - 3.13;95% CI -3.94, - 2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log(10) DBOLD response and the baseline T2* (r = -0.88, p <0.0001).Conclusion: The high hyperoxic DBOLD response demonstrated in pregnancies complicated by placental dysfunction may simply reflect altered baseline conditions, as the absolute increase in placental oxygenation (Delta T2*) does not differ between groups. (c) 2017 Elsevier Ltd. All rights reserved.

KW - BOLD MRI

KW - Magnetic resonance imaging

KW - Placental dysfunction

KW - Placental oxygenation

KW - T2 relaxation

KW - 1.5 T

KW - FETAL ARTERIAL

KW - OXYGENATION

KW - PULSATILITY INDEX

KW - T2relaxation

KW - PHYSIOLOGICAL-BASIS

KW - MAGNETIC-RESONANCE

KW - RELAXATION-TIME MEASUREMENTS

KW - GROWTH RESTRICTION

KW - BLOOD

KW - PRIMATE PLACENTA

KW - Pregnancy Trimester, Second

KW - Up-Regulation

KW - Humans

KW - Hyperoxia/diagnostic imaging

KW - Pregnancy Trimester, Third

KW - Case-Control Studies

KW - Placenta/blood supply

KW - Placental Circulation

KW - Adult

KW - Female

KW - Severity of Illness Index

KW - Reproducibility of Results

KW - Vascular Resistance

KW - Placentation

KW - Prenatal Diagnosis

KW - Magnetic Resonance Angiography

KW - Fetal Growth Retardation/etiology

KW - Pregnancy Complications, Cardiovascular/diagnostic imaging

KW - Peripheral Vascular Diseases/diagnostic imaging

KW - Pregnancy

KW - Magnetic Resonance Imaging

KW - Placenta Diseases/diagnostic imaging

UR - http://www.scopus.com/inward/record.url?scp=85034015430&partnerID=8YFLogxK

U2 - 10.1016/j.placenta.2017.11.002

DO - 10.1016/j.placenta.2017.11.002

M3 - Journal article

VL - 61

SP - 17

EP - 23

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - 1

ER -